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Heart quieting and nerve soothing capsules and preparation method thereof

A technology for calming the mind and calming the nerves and capsules, which can be used in capsule delivery, pharmaceutical formulations, nervous system diseases, etc. It can solve the problems of low content of active ingredients, inconvenient taking, and large patient dosage, and achieve stable active ingredients and no active ingredients. The effect of destroying and inhibiting cell proliferation

Inactive Publication Date: 2016-10-12
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method in the prior art has rough and backward process, many impurities, and low active ingredient content, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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  • Heart quieting and nerve soothing capsules and preparation method thereof
  • Heart quieting and nerve soothing capsules and preparation method thereof
  • Heart quieting and nerve soothing capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 100g of coptis, 50g of amber, 250g of calamus, 417g of polygala, 417g of Poria cocos, 417g of salvia miltiorrhiza, 250g of licorice, 417g of red dates, 833g of wheat, 833g of calcined magnetite, 833g of mother of pearl, and the above ten flavors, add water 10 times the weight of the medicinal materials, Soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of medicinal materials to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine the two decoction liquids, concentrate to 60°C and the relative density is 1.05, add ethanol Make the volume percentage of the alcohol content reach 75%, stir, stand still, filter, the relative density of the filtrate is 1.25 when the filtrate is concentrated to 65°C, and recover ethanol to obtain a concentrated solution, use supercritical extraction to obtain a supercritical extract, and continue to concentrate , dry the concentrated solution, granulate, and fill capsules to obtain Ningxin Anshen Capsules. ...

Embodiment 2

[0032] Take 100g of coptis, 50g of amber, 250g of calamus, 417g of polygala, 417g of Poria cocos, 417g of salvia miltiorrhiza, 250g of licorice, 417g of red dates, 833g of wheat, 833g of calcined magnetite, 833g of mother of pearl, and the above ten flavors, add water 10 times the weight of the medicinal materials, Soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of medicinal materials to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine the two decoction liquids, concentrate to 60°C and the relative density is 1.05, add ethanol Make the volume percentage of the alcohol content reach 75%, stir, stand still, filter, the relative density of the filtrate is 1.25 when the filtrate is concentrated to 65°C, and recover ethanol to obtain a concentrated solution, use supercritical extraction to obtain a supercritical extract, and continue to concentrate , dry the concentrated solution, granulate, and fill capsules to obtain Ningxin Anshen Capsules. ...

Embodiment 3

[0036] Take 100g of coptis, 50g of amber, 250g of calamus, 417g of polygala, 417g of Poria cocos, 417g of salvia miltiorrhiza, 250g of licorice, 417g of red dates, 833g of wheat, 833g of calcined magnetite, 833g of mother of pearl, and the above ten flavors, add water 10 times the weight of the medicinal materials, Soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of medicinal materials to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine the two decoction liquids, concentrate to 60°C and the relative density is 1.05, add ethanol Make the volume percentage of the alcohol content reach 75%, stir, stand still, filter, the relative density of the filtrate is 1.25 when the filtrate is concentrated to 65°C, and recover ethanol to obtain a concentrated solution, use supercritical extraction to obtain a supercritical extract, and continue to concentrate , dry the concentrated solution, granulate, and fill capsules to obtain Ningxin Anshen Capsules. ...

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Abstract

The invention provides a preparation method for heart quieting and nerve soothing capsules. The preparation method comprises the following steps: weighing 100 grams of coptis chinensis, 50 grams of ambers, 250 grams of acorus gramineus, 417 grams of processed radix polygalae, 417 grams of wolfiporia extensa, 417 grams of salvia miltiorrhiza, 250 grams of licorice, 417 grams of red dates, 833 grams of wheat, 833 grams of calcined magnets and 833 grams of mother pearls, adding water in an amount which is 10 times the weight of the medicinal materials, performing impregnation for 0.5 h, performing decoction for 1 h, performing filtration, adding water in an amount which is 8 times of the weight of the medicinal materials into decoction dregs, performing decoction for 1 h, filtering medicinal liquor, mixing the decoction, concentrating the mixed decoction to relative density of 1.05 at 60 DEG C, adding ethanol until the volumetric ethanol content reaches 75 percent, performing stirring, standing and filtration, concentrating the filtrate to relative density of 1.25 at 65 DEG C, recycling the ethanol to obtain a concentrated solution, performing supercritical extraction to obtain supercritical extract, continuing concentration, drying the concentrated solution, and performing granulation and capsule filling to obtain the heart quieting and nerve soothing capsules. Special concentration and drying equipment is adopted, and the prepared heart quieting and nerve soothing capsules are high in extract content, and are found to be applied to preparation of a medicament for suppressing proliferation of HEK-293 cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extraction, in particular to a Ningxin Anshen capsule and a preparation method thereof. Background technique [0002] Ningxin Anshen Capsule, calms the nerves, widens the chest and calms the mind. For menopause syndrome, neurasthenia. The preparation method in the prior art has a rough and backward process, many impurities, and low content of active ingredients, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. Contents of the invention [0003] Purpose of the invention: In order to solve the above problems, the purpose of the present invention is to provide a Ningxin Anshen capsule and a preparation method thereof. [0004] Technical scheme: the purpose of the present invention is achieved by the following scheme: [0005] A kind of Ningxin Anshen Capsules, the preparation method is...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/48A61P15/12A61P25/00A61P13/12A61K33/26A61K35/618A61K35/10
CPCA61K33/26A61K35/10A61K35/618A61K36/076A61K36/484A61K36/537A61K36/69A61K36/718A61K36/725A61K36/888A61K36/899A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2300/00
Inventor 卞毓平
Owner NANJING ZHENGKUAN MEDICAL TECH
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