Polymerizable quaternary ammonium salt modified anti-microbial pit and fissure sealant and preparation method thereof

A technology of polymerizing quaternary ammonium salts and antibacterial sockets, which is applied in dental preparations, pharmaceutical formulations, dental prostheses, etc., can solve the problems of reduced crosslinking degree and mechanical properties of materials, and achieves strong surface adsorption, short curing time, good fluidity

Inactive Publication Date: 2016-10-12
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, currently commonly used quaternary ammonium salt monomers such as MDPB and DMAE-CB contain only one polymeric functional group, and form a linear compound when copolymerized with the matrix monomer. If the content of the antibacterial component is too high, the degree of crosslinking decreases, and the material The mechanical properties will also decrease

Method used

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  • Polymerizable quaternary ammonium salt modified anti-microbial pit and fissure sealant and preparation method thereof
  • Polymerizable quaternary ammonium salt modified anti-microbial pit and fissure sealant and preparation method thereof
  • Polymerizable quaternary ammonium salt modified anti-microbial pit and fissure sealant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An antibacterial pit and fissure sealant, comprising: 50% to 60% bisphenol A bisglycidyl methacrylate BisGMA, 25% to 30% triethylene glycol dimethacrylate TEGDMA, 8% to 10% hydroxyethyl methacrylate HEMA, 1% to 10% silanized nano-scale silica, 1% to 5% dimethylacryloyloxyethyl-n-dodecyl - Methylammonium bromide MAE-DB, 0.5-3% NaF, 0.1%-1% photoinitiating mixture (ethyl dimethylaminobenzoate: camphorquinone ratio: 1:1.2-1:2), 0.3% ~2% colorant titanium dioxide, 0.001%~0.01% 2.5-di-tert-butyl hydroquinone.

[0031] The preparation method of the above-mentioned antibacterial pit and fissure sealant comprises the following steps:

[0032] 1) Take triethylene glycol dimethacrylate TEGDMA and bisphenol A bisglycidyl methacrylate (BisGMA), mix thoroughly to obtain component A; take dimethylacryloyloxyethyl-n- Lauryl-methylammonium bromide MAE-DB and hydroxyethyl methacrylate HEMA are thoroughly mixed to obtain component B; components A and component B are fully mixed to obta...

Embodiment 2

[0036]An antibacterial pit and fissure sealant, in terms of mass percentage, comprising: 53% to 62% of urethane dimethacrylate UDMA, 20% to 26% of triethylene glycol dimethacrylate TEGDMA , 10% to 12% of hydroxyethyl methacrylate HEMA, 5% to 10% of polymethacrylate polymer nanoparticles VP (502), 1% to 5% of methacryloyloxyethyl- N-hexadecyl-dimethylammonium chloride DMAE-CB, 0.5-3% NaF, 0.1%-1% photoinitiating mixture (ethyl dimethylaminobenzoate: camphorquinone ratio: 1:1.5-1 : 1.7), 0.1% to 0.6% of the colorant titanium dioxide, 0.001% to 0.03% of p-phenol monobutyl ether.

[0037] The preparation method is the same as in Example 1.

Embodiment 3

[0039] An antibacterial pit and fissure sealant, comprising: 48% to 60% bisphenol A bisglycidyl methacrylate BisGMA, 18% to 26% triethylene glycol dimethacrylate TEGDMA, 10% to 12% hydroxyethyl methacrylate HEMA, 5% to 10% polymethacrylate polymer nanoparticles VP (362), 1% to 5% methacryloyloxyethyl -N-hexadecyl-dimethylammonium chloride DMAE-CB, 1~2% NaF, 0.1%~1% photosensitive trigger mixture (ethyl dimethylaminobenzoate: camphorquinone ratio: 1:1.5- 1:2), 0.1% to 0.6% of the colorant titanium dioxide, 0.03% to 0.05% of hydroquinone.

[0040] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a polymerizable quaternary ammonium salt modified anti-microbial pit and fissure sealant and a preparation method thereof and belongs to the technical field of medical materials for the oral cavity. The polymerizable quaternary ammonium salt modified anti-microbial pit and fissure sealant is prepared from 40%-80% of resin monomer matrixes, 15%-40% of a reactive diluent, 3%-25% of functional monomers, 0.5%-10% of polymerizable quaternary ammonium salt monomers, 1%-20% of nanoscale filler, 0.5%-3% of NaF, 0.05%-3% of a photosensitive initiation mixture, 0.001%-0.05% of a polymerization inhibitor and 0.3%-5% of pigment. The pit and fissure sealant has good biological safety, is short in curing time at the temperature of the oral cavity and long in operation time and has an effective and lasting antibacterial effect; the preparation method is simple to operate, environment-friendly and suitable for industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of oral medical materials, and relates to an antibacterial pit and fissure sealant for pit and fissure sealing, in particular to an antibacterial pit and fissure sealant which can be modified by a polymerizable quaternary ammonium salt and a preparation method thereof. Background technique [0002] The depressions that exist on the occlusal surfaces of the posterior teeth in the human oral cavity are called pits and fissures. It can play the role of increasing the chewing area and increasing friction, which is conducive to fully chewing food. The pits and fissures of molars are more numerous and deeper than those of bicuspids, and are more obvious in permanent teeth. The depth and shape of pits and fissures vary. A typical molar pit and fissure can be as deep as 1.5 mm, and the diameter of the groove is only 0.5 mm. Some porous structures can only be seen under a high-power magnifying glass. However, it ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/20C08F222/22C08F220/28C08F222/14C08K3/36A61K6/00
CPCA61K6/19A61K6/60A61K6/62A61K6/71A61K6/76C08F222/20C08F222/22C08K3/36C08K2201/011C08F222/102C08F220/281
Inventor 陈吉华常刚唐立辉黄鹂夏雨凝杨彦伟
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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