Light sheet microscopic imaging conversion apparatus
A technology for microscopic imaging and conversion devices, which can be used in measuring devices, fluorescence/phosphorescence, and material analysis through optical means, and can solve the problems that an inverted microscope cannot be converted into a light-sheet imaging system, and achieve the effect of reducing costs
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[0030] Example 1
[0031] The light sheet microscopic imaging conversion device provided by the present invention, such as figure 1 As shown, the light sheet microscopy imaging conversion device provided by the present invention includes: a light sheet laser light source 1, a sample holder 2, and a mover 3. The preferred solution also includes a two-dimensional moving platform; the light sheet laser light source 1 , Generate a light sheet laser, and irradiate it horizontally on the sample 4 fixed to the sample holder 2; the mover 3 is connected with the sample holder 2 to drive the sample holder 2 to move in the vertical direction , The two-dimensional mobile platform is connected with the vertical movement and used for providing two-dimensional movement in the horizontal plane.
[0032] The light sheet laser light source 1 includes a light source 11, a light sheet generating part 12, the light source 11 is used for generating collimated laser light, and the light sheet generating ...
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[0040] Example 2
[0041] The heart development of transgenic fish embryos with flik green fluorescent protein was used as the observation object. Flik fluorescent protein is expressed in endothelial cells and cardiomyocytes, so the circulatory system of fish, including blood vessels, and the heart all emit green fluorescence under the action of excitation light. For example, using an ordinary wide-field illumination inverted fluorescence microscope to observe, due to the extensive out-of-focus light irradiation, the tissues around the heart are excited to fluoresce, the entire inverted image has low contrast and serious light pollution, and the cross-sectional image from the heart is not obvious. Such as Figure 4 Shown on the upper left side. After simply installing a light-sheet microscopy imaging conversion device, using the extremely thin light-sheet illumination produced by the accessory can almost completely eliminate the pollution of out-of-focus light, and the obtained...
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