Tacrolimus ointment and preparation method thereof

Abstract

The invention provides tacrolimus ointment and a preparation method thereof. The tacrolimus ointment is prepared from the following components in parts by weight, 0.001-0.1 part of tacrolimus, 1-17.4 parts of light liquid paraffin, 0.1-1 part of paraffin, 0.1-7.5 parts of propylene glycol, 5-72 parts of white petrolatum, 0.1-2 parts of white beeswax and 0.1-10 parts of calamine powder. The preparation method comprises the following steps: (1) adding a formulated quantity of matrix components into an emulsification tank of an emulsifying mixer, heating the matrix components to 90 DEG C, mixing the matrix components for 20 minutes to completely dissolve the matrix components, leading condensate water into the emulsification tank and cooling materials to 70 DEG C for standby application; (2) adding a formulated quantity of the propylene glycol, magnetically mixing the materials for 60 minutes to dissolve the propylene glycol, and heating the materials to 70 DEG C in a water bath; (3) adding tacrolimus solution into an ointment matrix at the same temperature and homogenizing the tacrolimus solution; (4) detecting and sub-packaging semi-finished products; (5) capping the tail part of the filled ointment by a capper; (6) packaging and warehousing the ointment. The method is simple, the ointment avoids adverse side effects caused by glucocorticoids, and a good solution is provided for specific skin diseases.

Description

technical field [0001] The invention relates to the technical field of medicaments and preparation thereof, in particular to a tacrolimus ointment and a preparation method thereof. Background technique [0002] At present, the medical community believes that atopic dermatitis (Atopic Dermatitis, AD) is a kind of allergic skin disease with genetic predisposition. 70% of the patients have a history of genetic allergies such as allergies, asthma or allergic rhinitis in their families, so it is also called AD. Atopic eczema, atopic dermatitis, atopic dermatitis, generalized neurodermatitis, etc., most patients are caused by repeated attacks and delays of infantile eczema. Atopic dermatitis is a chronic, pruritic, inflammatory skin disease. [0003] Atopic dermatitis is closely related to genetic factors, allergic factors, abnormal immune response, abnormal blood vessel and blood vessel drug response, mental factors, infection, climate and living environment. Studies have shown...

AI Technical Summary

Problems solved by technology

[0004] In recent decades, external use of corticosteroid-containing drugs for atopic dermatitis is affirmative, and it can be selected for mild or small-scale dermatitis; Hormone drugs have systemic and local skin side effects, let alone systemic side effects, and local skin side effects remind us to choose carefully