Nauclea officinalis pierre ex pitard total alkaloid extract, as well as preparation method and application thereof

A technology for total alkaloids and extracts, which is applied in the field of total alkaloid extracts and their preparations, can solve the problems of unclear effective parts of anti-inflammatory activity, and achieve the effect of significant effect and anti-inflammatory effect.

Active Publication Date: 2016-11-09
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI HAINAN BRANCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the preparations such as Danmu injection and Danmu extract tablets produced with Danmu as raw materials have been clinically used for many years with definite curative effects, the production of their preparations still uses the crude extract of Danmu water as raw material, and its anti-inflammatory activity The effective site is not yet clear

Method used

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  • Nauclea officinalis pierre ex pitard total alkaloid extract, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of the total alkaloid extract provided by the invention, the steps are as follows:

[0031] S1: Take the branches of the eucalyptus, crush them through a 40-mesh sieve, add 70% ethanol at a volume concentration, reflux and extract at 30° C., and filter to obtain the eucalyptus extract. The amount of ethanol is 8 times the quality of the medicinal material;

[0032] S2: concentrating the extract of Alba japonica under reduced pressure to a concentrated solution with a relative density of 1.15 at 60°C;

[0033] S3: adding the concentrated solution into purified water, heating to 30°C, stirring to dissolve, and filtering to obtain an aqueous solution of gallwood, the volume ratio of the amount of purified water to the concentrated solution of gallwood is 1:0.5;

[0034] S4: adding 2% hydrochloric acid solution by volume to the aqueous solution of birchwood, adjusting the pH value to 2.0 to obtain an acid treatment solution;

[0035] S5: After the ac...

Embodiment 2

[0041] The preparation method of the total alkaloid extract provided by the invention, the steps are as follows:

[0042] S1: take the stems of the eucalyptus, crush them through a 60-mesh sieve, add 75% ethanol with a volume concentration of 40°C for reflux extraction, and filter to obtain the eucalyptus extract. The amount of ethanol is 9 times the mass of the medicinal material;

[0043] S2: concentrating the extract of Alba japonica under reduced pressure to a concentrated solution with a relative density of 1.18 at 60°C;

[0044] S3: add the concentrated solution into purified water, heat to 40°C, stir to dissolve, and filter to obtain an aqueous solution of gallwood. The volume ratio of the amount of purified water to the concentrated solution of gallwood is 1:1;

[0045] S4: adding 1% hydrochloric acid solution by volume to the aqueous solution of birchwood, adjusting the pH value to 4.0 to obtain an acid treatment solution;

[0046] S5: After the acid treatment soluti...

Embodiment 3

[0052] The preparation method of the total alkaloid extract provided by the invention, the steps are as follows:

[0053] S1: Take the stems of the eucalyptus, crush them through an 80-mesh sieve, add 80% ethanol at a volume concentration, reflux extraction at 50°C, and filter to obtain the eucalyptus extract. The amount of ethanol is 10 times the mass of the medicinal material;

[0054] S2: concentrating the extract of Alba japonica under reduced pressure to a concentrated solution with a relative density of 1.25 at 60°C;

[0055] S3: add the concentrated solution into purified water, heat to 50°C, stir to dissolve, and filter to obtain an aqueous solution of gallwood. The volume ratio of the amount of purified water to the concentrated solution of gallwood is 1:2;

[0056] S4: adding 2% hydrochloric acid solution by volume to the aqueous solution of birchwood, adjusting the pH value to 3.0 to obtain an acid treatment solution;

[0057] S5: After the acid treatment solution ...

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Abstract

The invention provides nauclea officinalis pierre ex pitard total alkaloid extract, which comprises 3-R-3,4-dihydroangustoline, naucleofficine D, 1,2,3,4-tetrahydro-beta-carboline, 3-S-3,4-dihydroangustoline, latifoliamide D, latifoliamide B, angustoline, 3,14-dihydroangustine, 3,14,18,19-tetrahydroangustine, 6'-acetyl strictosamide, vincoside lactam and strictosamide. The content of total alkaloids in the nauclea officinalis pierre ex pitard total alkaloid extract obtained by such a preparation method is more than 50 weight percent. The nauclea officinalis pierre ex pitard total alkaloid extract obtained by the preparation method and a medicinal composition prepared from the nauclea officinalis pierre ex pitard total alkaloid extract have better anti-inflammatory effects.

Description

technical field [0001] The invention relates to natural medicines, in particular to an extract of total alkaloids of birchwood and its preparation method and application. Background technique [0002] Nauclea officinalis Pierre ex Pitard is a plant of Rubiaceae ebony, also known as ebony, fine-leaved yellow tree, yellow sheep wood, mountain bear bile, and bear bile tree. There are about 35 species of Ebony, distributed in tropical Asia, Africa and Oceania. Danmu likes to be born near the top of a mountain or in a hidden and humid area in the middle of a mountain, and is distributed in tropical Asia (China, Cambodia), Africa and Oceania. In my country, it only exists in the deep mountains of Hainan, Yunnan, and Guangxi. The distribution is narrow, the population is small, and it is sporadic. It is a rare tree species in middle-altitude forests. Gallwood is an arbor, 4-12 meters high, the trunk skin is yellowish brown, rough, loose, and easy to peel off; yellow, the xylem is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P29/00
Inventor 杨新全陈德力马国需何明军刘洋洋杨云
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI HAINAN BRANCH
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