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Formula of motion sickness resisting plaster and preparation method

A motion sickness and medicine film technology, applied in the field of medicine, can solve problems such as restricting head movement and difficulty in concentrating

Inactive Publication Date: 2016-11-23
卢卫红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, prevention and control measures include restriction of head movement, oral administration and mastoid administration. The drugs given, such as scopolamine hydrobromide, dimenhydrinate, dimenhydrinate, meclizine, etc., have symptoms of dry mouth, lethargy, Difficulty concentrating and other side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0005] Specific embodiment 1: In this embodiment, a kind of anti-motion sickness medicine film formula and preparation method are characterized in that: 1. It is composed of the weight and number ratio of the following components: perilla 5-10, ginger 3-7 , orange peel 1-5, mint 1-5. 2. Extraction: add distilled water, the ratio of solid to liquid is 1:10, heat under reflux for 5h, filter to obtain the residue and extract; after the extract is concentrated under reduced pressure, 2 times the amount of n-butanol is repeatedly extracted 4 times, and the layers are left to stand to obtain The upper layer is the n-butanol extract, and the lower layer is the water extract; after drying the residue, add 95% ethanol, the ratio of solid to liquid is 1:10, sonicate for 5 hours, and filter to obtain the ethanol extract. The n-butanol extract, the water extract and the ethanol extract were respectively concentrated, centrifuged at 4000rpm / min, and vacuum-dried to obtain three different c...

specific Embodiment approach 2

[0006] Embodiment 2: This embodiment is different from Embodiment 1 in that it is characterized in that the ratio of parts by weight of components is: perilla 10, ginger 7, orange peel 5, mint 5. Others are the same as the first embodiment.

specific Embodiment approach 3

[0007] Embodiment 3: This embodiment is different from Embodiment 1 in that it is characterized in that in step 3, the simulated motion adopts the halo stimulation method of alternation of cis-reverse and variable-speed rotation. The specific parameters are: 30° / s 2 Rotate with angular acceleration for 10s, rotate at a constant speed for 35s after reaching the maximum peak speed of 300° / s, and then rotate at 30° / s 2 The angular acceleration is decelerated for 10s until the angular velocity is 0, and after stopping for 5s, it rotates in the opposite direction in the same way. During this period, it alternates forward and reverse 20 times, totaling 40min. Others are the same as the first embodiment.

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PUM

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Abstract

Motion sickness is a disease with a series of vestibule and vegetative nerve reactions, such as dizziness, giddiness, nausea, vomiting, pale complexion and cold sweat, as main clinical manifestation. The motion sickness comprises carsickness, seasickness, airsickness and space sickness. The invention relates to a formula of a motion sickness resisting plaster and a preparation method. According to the external use formula, the contact face of the plaster and the acupoint is good, side effects are small, the acting time is long, drug administration is convenient, and the drug utilization rate is high. After three kinds of different chemical constituents are selected to feed experimental animals, simulating motion is carried out, the constituent with the best preventing effect is screened out, a soft matrix accessory is used for manufacturing a stereoscopic netty support to serve as a carrier, the support is filled with medicine extract, and a film sheet is made. After the product is sticked to the acupoint, along with slow decomposition of the carrier, effective ingredients are slowly released, and therefore the effective acting time of the medicine is prolonged.

Description

technical field [0001] The invention relates to the field of medicine, and relates to a slow-release medicine film formula with anti-motion sickness for acupoint administration. Background technique: [0002] Motion sickness is a disease with a series of vestibular and autonomic reactions such as dizziness, vertigo, nausea, vomiting, pale complexion, and cold sweats as the main clinical manifestations when riding a vehicle. Including motion sickness, seasickness, airsickness and space sickness. With the rapid development of manned spaceflight and aviation flight, the emergence and prevention of motion sickness have become increasingly prominent problems. The symptoms of spaceflight motion sickness are similar to motion sickness that occurs when a person is on a ship or plane on the ground. At present, prevention and control measures include restriction of head movement, oral administration and mastoid administration. The drugs given, such as scopolamine hydrobromide, dimen...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/70A61P1/08
Inventor 卢卫红赵姣井晶
Owner 卢卫红
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