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Antiseptic dressing containing nanogold and preparing method thereof

A technology of nano-gold and nano-gold particles, which is applied in the fields of pharmaceutical formula, medical science, bandages, etc., to achieve enhanced antibacterial effect, long-term antibacterial performance, and easy industrial production.

Inactive Publication Date: 2016-11-23
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no public literature at home and abroad to report that antibacterial dressings made of gold nanoparticles with broad-spectrum antibacterial properties and low cytotoxicity will have excellent broad-spectrum antibacterial properties, no bacterial drug resistance, and antibacterial nano-gold with low cytotoxicity to human cells. Gold is added to the dressing, making it an antibacterial dressing with high-efficiency broad-spectrum antibacterial properties and higher safety

Method used

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  • Antiseptic dressing containing nanogold and preparing method thereof
  • Antiseptic dressing containing nanogold and preparing method thereof
  • Antiseptic dressing containing nanogold and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] This embodiment is used to illustrate the nano-gold-containing antibacterial dressing of the present invention and its preparation method.

[0048] The preparation method of the nano gold-containing antibacterial dressing of the present embodiment comprises:

[0049] (1) Prepare a coating liquid containing gold nanoparticles. The gold-containing nanoparticle coating solution is gold-platinum two-component Au 80 Pt 20 (that is, the atomic percentage of platinum is 20%) the nanoparticle coating solution, the concentration is 300ppm. The preparation method of this coating solution can be: prepare the mixed solution of chloroauric acid, potassium chloroplatinate and Tween 80 whose volume content accounts for 10%, then reduce the mixed solution with reducing agent sodium borohydride in an ice-water bath to obtain Gold-platinum two-component Au 80 Pt 20 Nanoparticle coating solution. More detailed preparation methods can be found in Zhao Y, Ye C, Liu W, et al. Tuning th...

Embodiment 2

[0055] This embodiment is used to illustrate the nano-gold-containing antibacterial dressing of the present invention and its preparation method.

[0056] The preparation method of the nano gold-containing antibacterial dressing of the present embodiment comprises:

[0057] (1) Prepare a coating liquid containing gold nanoparticles. The coating solution containing gold nanoparticles is a coating solution of gold nanoparticles modified by two components of 2-mercapto-4,6-diaminopyrimidine / 1-(3-chlorophenol) biguanide, and the concentration is 400 ppm. The preparation method of this coating solution can be: dissolving and mixing chloroauric acid, 2-mercapto-4,6-diaminopyrimidine and 1-(3-chlorophenol) biguanide to form a mixed solution (the volume content that can be added accounts for 0.1 % Tween 80), and then reduce the mixed solution with reducing agent sodium ascorbate to obtain a gold nanoparticle coating solution modified by 2-mercapto-4,6-diaminopyrimidine / 1-(3-chlorophe...

Embodiment 3

[0063] This embodiment is used to illustrate the nano-gold-containing antibacterial dressing of the present invention and its preparation method.

[0064] The preparation method of the nano gold-containing antibacterial dressing of the present embodiment comprises:

[0065] (1) Prepare a coating liquid containing gold nanoparticles. The coating solution containing gold nanoparticles is a coating solution of gold nanoparticles modified by two components of 2-mercapto-4,6-diaminopyrimidine / 1-(3-chlorophenol) biguanide, and the concentration is 400 ppm. Its preparation method is identical with embodiment 2.

[0066] (2) Padding: Add the coating liquid containing gold nanoparticles into a padding tank, and then pad the base material nylon cloth in the padding tank, so that the coating liquid is evenly coated on the nylon cloth. The impregnated rate of the base material after padding was 30%, and the padding speed was 100 m / min. The padding tank is connected with a feeding barre...

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Abstract

The invention provides antiseptic dressing containing nanogold. The antiseptic dressing comprises a base material and nanogold particles which adhere to the base material and have an antiseptic effect. The invention further provides a preparing method and application of the antiseptic dressing containing nanogold. The gram-negative bacterium and gram-positive bacterium resisting performance of the antiseptic dressing containing nanogold is higher; furthermore, cytotoxicity tests and animal experiments prove that the toxicity of the antiseptic dressing containing nanogold is far lower than that of medical nanosilver dressing using nanosilver.

Description

technical field [0001] The invention relates to an antibacterial dressing, in particular to an antibacterial dressing containing gold nanometers, and a preparation method and application of the antibacterial dressing containing gold nanometers. Background technique [0002] Medical dressings are necessary consumer goods in hospitals and are consumed in large quantities. Antibacterial dressings have the functions of sterilization and anti-infection, which can protect patients from infection and promote healing. They have been widely used in surgery, internal medicine, burns, and otolaryngology in hospitals. At present, the commonly used antibacterial dressings on the market are antibacterial dressings containing nano-silver. Nano-silver has a strong broad-spectrum antibacterial effect, has no drug resistance to bacteria, and is an effective antibacterial agent. However, nano-silver is unstable and has certain toxicity to the human body, and the safety of nano-silver dressin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/44
CPCA61L15/18A61L15/46A61L2300/102A61L2300/404A61L2400/12
Inventor 蒋兴宇孟宏宇张伟
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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