Biosensing marking method, biosensing marking system and disease detection system

Abstract

The invention discloses a biosensing marking method, a biosensing marking system and a disease detection system. According to the biosensing marking method, antigens in a tested sample can be captured by first antibodies when part of optical fibers pass the tested sample by means of fixing a layer of the first antibodies of a tested biomarker on the surfaces of the optical fibers; second antibodies of the tested biomarker are then fixed to the surfaces of metal nanoparticles, the metal nanoparticles are mixed in the tested sample, and the metal nanoparticles can be bound with antigens in the tested sample through the second antibodies due to specific recognition of the second antibodies; detection of the antigens in the tested sample can be realized with the biosensing marking method. Since the cross section of extinction of the metal nanoparticles is far larger than that of the conventional fluorescent molecular, the biosensing marking method has higher antigen detection sensitivity than the conventional fluorescence labeling method.

Description

technical field [0001] The present application relates to the technical field of biosensing, and more specifically, relates to a biosensing calibration method, a calibration system and a disease detection system. Background technique [0002] At present, in the medical field, the cost of disease detection accounts for a large part of patients' medical expenses. How to reduce the cost of disease detection has become one of the directions of researchers' efforts. Biosensing technology has greatly reduced the amount of detection reagents and greatly reduced the manufacturing cost of detection instruments. Therefore, biosensing technology has become a key research direction in the field of medical detection. [0003] Fluorescent labeling is a widely used biosensing technology at present. Its specific principle is to label fluorescein on known antibodies or antigen molecules. After the antibody is combined to form a complex, a certain amount of fluorescein is carried on the comp...

AI Technical Summary

Problems solved by technology

However, the problem with the fluorescent labeling method is that the fluorescein in the complex will inevitably affect the properties of the antigen to be tested or the antibody to be tested, and this effect may cause damage to the carrier o

Images