Sample preparation device and method of preparing samples for sterility testing

A technology of sample preparation and operating position, applied in the direction of biochemical equipment and methods, methods of supporting/immobilizing microorganisms, measuring devices, etc., to achieve the effect of improving repeatability and avoiding contamination

Active Publication Date: 2021-03-02
MERCK PATENT GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0022] A general disadvantage of this procedure is that multiple external containers or vials with the culture or growth medium and substances used to create the anaerobic environment will be connected and disconnected from the sample preparation devices or containers used in each test task, and multiple definite steps requiring substantial operational effort will be performed in a predetermined and precisely repeatable procedure

Method used

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  • Sample preparation device and method of preparing samples for sterility testing
  • Sample preparation device and method of preparing samples for sterility testing
  • Sample preparation device and method of preparing samples for sterility testing

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Embodiment Construction

[0043] The sample preparation device of the present invention and the method of using the sample preparation device to prepare a sample for sterility testing will now be described below with reference to the schematic principle of the device and various specific examples of this principle.

[0044] figure 1 The sample preparation device 1 is shown with its basic structural elements. The sample preparation device 1 comprises a first chamber 2 containing a first movable piston / barrier 2c which makes a first volume above (upstream) the first piston / barrier 2c 2a is separated from the second volume 2b below (downstream) the first piston / barrier 2c. The second chamber 3 contains a second movable piston / barrier 3c which makes the third volume 3a above (upstream) the second piston / barrier 3c and below ( Downstream) the fourth volume 3b is separated. The entrance to the first volume 2a (in figure 1 not shown in ) and an outlet 5 from the first volume 2a is provided. The first vol...

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Abstract

The sample preparation device (1) comprises: a first chamber (2) containing a first movable piston (2C), the first volume (2A) upstream of the first piston (2C) and the first piston The second volume (2B) downstream of (2C) is divided; the second chamber (3) containing the second movable piston (3C) which makes the third volume (3A) upstream of the second piston (3C) ) and the fourth volume (3B) downstream of the second piston (3C); and the inlet (4; 4A) to and outlet (5) from the first volume (2A). The first volume (2A) is connected with the third volume (3A) through the first communication path (6), and the second volume (2B) is connected with the fourth volume (3B) through the second communication path (7).

Description

technical field [0001] The present invention relates to a sample preparation device, preferably for sterility and bioburden testing, eg suitable for testing purposes related to the control of manufacturing processes or for final product testing in the pharmaceutical, biotech, food and beverage industries. Background technique [0002] Sterility or bioburden testing procedures require sample preparation methods that involve specific consumables, hardware, and sample preparation steps and are known throughout the industry as standardized methods. In growth-based sterility testing, sample preparation involves promoting the growth of any microorganism to be tested by direct contact with a liquid nutrient medium and by incubating a container with a filter membrane and nutrient medium at a predetermined temperature. Culture medium is introduced over calibrated membrane filters that retain microorganisms. Changes in the turbidity of the nutrient medium indicate the presence of mic...

Claims

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Application Information

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IPC IPC(8): C12Q1/22
CPCC12Q1/22A61L2/28B01L3/502B01L2200/0684B01L2200/141B01L2300/042B01L2400/0457B01L2400/0478G01N1/4077G01N2001/4088C12M23/34C12M23/38C12M25/02
Inventor S.奥利维耶
Owner MERCK PATENT GMBH
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