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A kind of aspirin anhydrous swallowing taste masking granule and preparation method thereof

A technology of aspirin and taste-masking granules, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Waterless swallowing, complex preparation process and other problems, to achieve good coating effect, good swallowing taste, and the effect of optimizing taste

Active Publication Date: 2020-08-04
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because aspirin itself has a sour taste, it brings poor experience to patients, and ordinary dosage forms cannot avoid the decline in patient compliance caused by the smell of the drug
[0005] In order to reduce the stimulation of aspirin on the gastrointestinal tract, aspirin needs to be coated or made into aspirin enteric-coated tablets. For example, Chinese patent application 201310400888 discloses an aspirin enteric-coated tablet, but the enteric-coated tablet uses a large number of excipients, which cannot achieve effective The effect of masking the sour taste and anhydrous swallowing, and the preparation process is complicated, which still cannot meet the requirements of industrial production and clinical application

Method used

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  • A kind of aspirin anhydrous swallowing taste masking granule and preparation method thereof
  • A kind of aspirin anhydrous swallowing taste masking granule and preparation method thereof
  • A kind of aspirin anhydrous swallowing taste masking granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The ethanol solvent system is used for the packaging of the isolation gown and the enteric coat, and the specific parameters are as follows

[0039] prescription

[0040]

[0041] Preparation:

[0042] 1) Preparation of the isolation layer solution:

[0043] The prescribed amount of purified water and ethanol are fully mixed, and in the state of stirring, hypromellose 603 and polyethylene glycol 6000 are added, stirred until dissolved, and then talcum powder is added to form the final solution.

[0044] 2) Preparation of taste-masking layer solution

[0045] First, fully mix the prescribed amount of ethanol and purified water. Under stirring, add Eudragit E100 into the ethanol solution, stir until dissolved, add the prescribed amount of TEC, and stir for about 1 hour. Add talcum powder and Magnesium stearate, after stirring for 30 minutes, a uniform suspension is formed, and it is filtered with a 0.5mm sieve before coating.

[0046] Isolation coating parameters: ...

Embodiment 2

[0062] prescription

[0063]

[0064]

[0065] preparation:

[0066] 1) Preparation of the isolation layer solution:

[0067] Add hypromellose 603 and polyethylene glycol 6000 to the prescribed amount of purified water under stirring, stir until dissolved, and then add talcum powder to form a final solution.

[0068] 2) Preparation of taste-masking layer solution

[0069] First, dissolve sodium lauryl sulfate in the purified water of the prescribed amount, add stearic acid in the high-speed dispersion state, disperse to the dissolved state, add Eudragit EPO in the dispersed state, and disperse until no solid matter floats in the On the surface, add titanium dioxide, talcum powder, and simethicone to disperse for 30 minutes to form a uniform dispersion, and filter with a 0.5mm sieve before coating.

[0070] 3) List of isolation gown coating parameters:

[0071] craft item parameter batch 500g aspirin as base material Atomization pressure 1.2 ...

Embodiment 3

[0088]

[0089] 1) Preparation of the isolation layer solution:

[0090] Add hypromellose 603 and polyethylene glycol 6000 to the prescribed amount of purified water under stirring, stir until dissolved, and then add talcum powder to form a final solution.

[0091] 2) Preparation of taste-masking layer solution

[0092] First, dissolve sodium lauryl sulfate in the purified water of the prescribed amount, add stearic acid in the high-speed dispersion state, disperse to the dissolved state, add Eudragit EPO in the dispersed state, and disperse until no solid matter floats in the On the surface, add titanium dioxide, talcum powder, and simethicone to disperse for 30 minutes to form a uniform dispersion, and filter with a 0.5mm sieve before coating

[0093] Isolation gown coating parameter list:

[0094] craft item parameter batch 500g aspirin as base material Atomization pressure 1.2 bar material temperature 40±5℃ Liquid supply rate 9.4...

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Abstract

The invention provides a stable aspirin taste-masking particle capable of being swallowed without water. The particle is prepared by mixing a taste-masking-layer-coated pill with a taste-modifying material, wherein the taste-masking-layer-coated pill comprises three layers of structures of a medicine core, an isolation layer and a taste-masking layer from inside to outside; and the particle is prepared by performing isolation layer coating and taste-masking layer coating on a main medicine, namely, aspirin and medicinal auxiliary materials in sequence to obtain the taste-masking-layer-coated pill, and mixing the pill with the taste-modifying material. The aspirin taste-masking particle capable of being swallowed without the water optimizes the mouth feel, well achieves the effect of masking bad smells, and improves medicine-taking compliance of patients; and the aspirin taste-masking particle can be swallowed without the water, so that the patients can swallow the particle conveniently, and the production of different specifications of aspirin taste-masking particles is facilitated.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a stable and conveniently taken anhydrous aspirin taste-masking granule for swallowing and a preparation method thereof. Background technique [0002] Aspirin is a classic drug that has been used clinically for hundreds of years. As a traditional non-steroidal anti-inflammatory drug, it is used for antipyretic and analgesic. In the treatment of arthritis, etc., it is necessary to take medicine for a long time without stopping. Therefore, it is still the most widely used antipyretic, analgesic and anti-inflammatory drug in the world, and it is also used as a standard preparation for comparing other drugs. In addition, it has an antithrombotic effect in the body, can inhibit the release reaction of platelets, inhibit platelet aggregation, and is clinically used to prevent the onset of cardiovascular diseases. But aspirin not only tastes sour, but also stimulate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/616A61K47/38A61K47/12A61P29/00A61P7/02
Inventor 蔡状王锦刚朱德志
Owner 北京科信聚润医药科技有限公司
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