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Composition comprising oroxylin and used for treating leukemia and application of composition

A technology of phyllophyllin and its composition, which is applied in the field of anti-tumor drugs, can solve the problems of no phyllophyllin, etc., and achieve the effects of prolonging survival, enhancing vitality, and good clinical application prospects

Inactive Publication Date: 2017-02-15
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is currently no research report on the effect of celesteol on leukemia

Method used

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  • Composition comprising oroxylin and used for treating leukemia and application of composition
  • Composition comprising oroxylin and used for treating leukemia and application of composition
  • Composition comprising oroxylin and used for treating leukemia and application of composition

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Embodiment 1

[0020] This study mainly combines flavonoid anti-tumor compounds with anti-tumor drug tumor necrosis factor TNFα for the treatment of acute myeloid leukemia (AML). Through in vivo and in vitro studies, it has been found that phyllostrum can be combined with TNFα to enhance the effect.

[0021] 1. Experimental materials

[0022] 1.1 Reagents

[0023] (1) Oroxylin A was purchased from the Key Laboratory of Tumor Occurrence and Intervention in Jiangsu Province (China Pharmaceutical University), and the drug powder was prepared into a mother solution with a concentration of 0.5M with dimethyl sulfoxide (DMSO) before use , make up the required concentration with cell culture medium before use. All-trans retinoic acid (ATRA) was purchased from Sigma, USA, and dissolved in DMSO to prepare a mother solution with a concentration of 20 mM.

[0024] (2) Recombinant human tumor necrosis factor α (TNFα) was purchased from Prospec-Tany TechnoGene Co., Ltd. Before use, the powder was pre...

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Abstract

The invention belongs to the field of antineoplastic medicaments and discloses a composition comprising oroxylin and used for treating leukemia and application of the composition. Active ingredients of the medicine composition contain the oroxylin and tumor necrosis factors. The medicine composition has an excellent therapeutic effect on the leukemia, can be used to prepare anti-leukemia medicines and is high in clinical value.

Description

technical field [0001] The invention belongs to the field of antineoplastic drugs, and relates to a composition containing celesteol for treating leukemia and an application thereof. Background technique [0002] Oroxylin A is one of the active components of Scutellaria baicalensis. It has obvious antitumor effect and is a natural antitumor drug with broad application prospects. At present, many literatures have systematically studied the anti-tumor effect, induction of apoptosis and cycle arrest of melaleucain, and found that melaleucain has a significant growth inhibitory effect on human liver cancer cells HepG2 cultured in vitro, and has a significant effect on ICR. Mouse Experimental Xenograft S 180 It also has a significant growth inhibitory effect, and the inhibition rate can reach more than 40%. It acts on the poorly differentiated human gastric adenocarcinoma cell line BGC-823 and causes its cycle to arrest in the G2 / M phase, suggesting that celestialin can induce t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61P35/02A61K31/352
CPCA61K31/352A61K38/191A61K2300/00
Inventor 郭青龙魏立彬惠慧卢娜赵丽周煜新张晓博赵凯
Owner CHINA PHARM UNIV
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