Preparation method of Daphne chamaejasme total diterpenes and its use in pharmacy

A technology of Daphne chamaejasme and total diterpenes, applied in antiviral agents, organic chemistry, etc., can solve the problems that the polycyclic structure in the chemical synthesis pathway cannot be realized, and the grassland is seriously damaged, and achieves strong anti-HIV activity, low toxicity, The effect of high content
CN106432263BActive Publication Date: 2019-08-09FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2019-08-09

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Abstract

The invention belongs to the field of traditional Chinese medicine preparation, and relates to a method for enriching daphnane type total diterpenoid ingredients from a grassland poisonous weed-stellera chamaejasme L. and application of the daphnane type total diterpenoid ingredients in preparation of anti-HIV medicine. According to the method, the total diterpenoid ingredients are enriched from the thymelaeaceae plant-stellera chamaejasme L., anti-HIV activity testing and main active ingredient content determining are conducted on all components, and results show that the anti-HIV activity is in an obvious rising trend along with increasing of the content of the daphnane type total diterpenoid ingredients in the components; when the total diterpenoid content of the enriched components is higher than 27%, the extremely high anti-HIV activity is displayed, the EC50 value can reach 0.005 microgram or below, the selection index SI is larger than 2,000, and high efficiency and low toxicity are achieved. The method for quickly enriching the daphnane type total diterpenoids from the stellera chamaejasme L. is established, and the enriched total diterpenoids can be used for preparing the anti-HIV medicine.
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Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a preparation method of total diterpenes of Daphne chamaejasme and its use in pharmacy, in particular to a preparation method for enriching daphne-type total diterpenes from Daphne chamaejasme and its application in Use in the preparation of anti-HIV drugs. Background technique

[0002] Stellera chamaejasme (Stellera chamaejasme L.), commonly known as heartbroken grass, steamed bun flower, chervil, etc., is a perennial herb of the genus Stelleralinn in the family Thymelaeaceae. Its medicinal part is the root and is widely distributed in northeast and northwest my country. , southwest, and Nepal and other places, its nature is flat, bitter and pungent, poisonous, and has the effects of dispelling phlegm by dispelling water, destroying accumulation and killing insects. Folks have long been used to treat mustard moss, intractable skin diseases, chronic bronchitis a...

Claims

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