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Method for preparing freeze dried acanthopanax injectio

The technology of freeze-dried powder injection and Acanthopanax senticosus is applied in the field of preparation of freeze-dried powder injection of Acanthopanax senticosus for injection, which can solve the problems of human body injury, reducing the content of active ingredients in medicine, reducing the recovery of active ingredients and the like.

Active Publication Date: 2008-02-20
HEILONGJIANG JINJIU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing production method of Acanthopanax senticosus freeze-dried powder for injection has the disadvantages of low purity and low active ingredient content
ZL94107718.7 discloses a kind of "Acanthopanax extract and its production process, as well as the injection and freeze-dried powder injection containing the extract". Extraction, mixing the extracted liquid with the decolorizing liquid, etc., because the extraction process will reduce the recovery of active ingredients, and the recovered ingredients are single, and ethyl acetate is highly toxic and flammable, which will cause great harm to the human body. It is only suitable for laboratory research and is not suitable for industrial production; moreover, the patent mixes the distilled residue after extraction with the decolorization liquid at the end. Since the decolorization liquid is sugar and small molecules, it has a lot of impurities. It will greatly reduce the purity of the drug and reduce the content of the active ingredient of the drug, so in practical applications, the drug obtained by this method has the disadvantage of poor curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0004] Specific embodiment one: the preparation process of this embodiment includes the following steps: a. extracting the roots, rhizomes or stems of Acanthopanax by water or alcohol, so that the alcohol content reaches 80-88%; b. precipitating for more than 24 hours, Recover ethanol, add water and refrigerate for 24 hours; c. Adsorb with macroporous adsorption resin, then elute the adsorption resin with ethanol, recover and elute the ethanol liquid, and recover ethanol until there is no alcohol smell; d. Add water, refrigerate, filter, sterilize, and aseptic Subpackage, freeze-dry, and pack.

specific Embodiment approach 2

[0005] Specific embodiment two: the preparation process of this embodiment is as follows: get 40000g-50000g of Radix Acanthopanax stem powder (piece or section) or root powder (piece or section), add water and decoct three times, each time 2 hours, the amount of water added is 8 Double the amount to 10 times the amount, filter several times, combine the filtrates, concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.10-1.15 (measured at 80°C), add ethanol to make the alcohol content reach 75%-88%, and let it stand After 24 hours, filter, recover the ethanol from the filtrate and concentrate it to an extract with a relative density of 1.20-1.25 (measured at 80°C), add 2-3 times the amount of crude drug in water and refrigerate for 24 hours, filter, and add the filtrate to the macroporous adsorption resin In the column, the type of adsorption resin used is AB-8 type, and then flows out at a flow rate of 1500-4000ml / s. The amount of ethano...

specific Embodiment approach 3

[0007] Specific embodiment three: the present embodiment gets Acanthopanax rhizome powder (or section or section) 40000g~50000g, adds 75%~88% ethanol reflux extraction 3 times, every time 2~3 hours, the amount of ethanol added is 8 ~10 times, filter in stages, let stand for 24 hours, filter, recover ethanol from the filtrate and concentrate to extract with relative density of 1.20~1.25 (measured at 80°C), add 2~3 times the amount of crude drug in purified water or inject Water, refrigerate for 24 hours, filter the infusion and add it to a macroporous adsorption resin column. The macroporous adsorption resin used is AB-8. After adsorption, first wash with water, and then use ethanol with a mass concentration of 80% to 85%. Elution, collect the ethanol eluate, recover the ethanol and concentrate to a clear paste with a relative density of 1.10-1.15 (measured at 80°C), let it cool, add 4 to 5 times the amount of water for injection, refrigerate for 24 hours, filter, add the filtra...

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Abstract

The invention relates to a method for preparing freeze dried acanthopanax injection which comprises the steps of, (1) subjecting the root, rhizome or stem of acanthopanax root to water extraction or alcohol extraction, (2) depositing for over 24 hours, reclaiming ethanol, charging water, cold storing 24 hours, (3) adsorbing with macroscopic adsorption resin, adsorbing resin through ethanol purging, reclaiming and purging the ethanol liquid, reclaiming ethanol till no alcohol smell is present, (4) charging water, cold storing and filtering, sterilizing, asepsis split charging, freeze-drying, and packaging.

Description

Technical field: [0001] The invention relates to a production method of Acanthopanax senticosus freeze-dried powder for injection. Background technique: [0002] The existing production method of Acanthopanax senticosus freeze-dried powder for injection has the disadvantages of low purity and low active ingredient content. ZL94107718.7 discloses a kind of "Acanthopanax extract and its production process, as well as the injection and freeze-dried powder injection containing the extract". Extraction, mixing the extracted liquid with the decolorizing liquid, etc., because the extraction process will reduce the recovery of active ingredients, and the recovered ingredients are single, and ethyl acetate is highly toxic and flammable, which will cause great harm to the human body. It is only suitable for laboratory research and is not suitable for industrial production; moreover, the patent mixes the distilled residue after extraction with the decolorization liquid at the end. Sin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/254A61K9/19
Inventor 李伟军邢印田施海平张清波徐丽华姜滨
Owner HEILONGJIANG JINJIU PHARMA
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