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Application of anticancer small molecule compound sorafenib in the treatment of hepatic echinococcosis

A technology of sorafenib and compounds, applied in the field of application of anticancer small molecule compound sorafenib and its analogues in the treatment of hepatic echinococcosis, which can solve the problems of large side effects and no very effective therapeutic drugs

Active Publication Date: 2020-07-03
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently no effective treatments
[0005] Mebendazole and albendazole are the preferred adjuvant therapy drugs before and after surgical excision of lesions, but they have relatively large side effects, and the main effect on parasites is inhibition rather than insecticidal effect

Method used

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  • Application of anticancer small molecule compound sorafenib in the treatment of hepatic echinococcosis
  • Application of anticancer small molecule compound sorafenib in the treatment of hepatic echinococcosis
  • Application of anticancer small molecule compound sorafenib in the treatment of hepatic echinococcosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] The Killing Effect of Sorafenib on Echinococcus

[0099] In this example, the killing efficiency of sorafenib on cultured cysts was evaluated at concentrations of 10 μM and 30 μM, respectively. Experimental protocol see figure 2 , the specific method is as follows:

[0100] 1.1. Mouse passage of Echinococcus

[0101] 1) Inoculate protoscoleum into the abdominal cavity of mice (500 protoscolmets per mouse), and dissect the mice after 3-5 months, separate the mass, and purify the protoscole.

[0102] 2) Repeated inoculation and subculture.

[0103] 1.2. Culture of alveolar hydatid cysts

[0104] 1) Culture hepatic parenchymal cells in RPMI-1640 medium for one week (37°C, 5% CO 2 ).

[0105] 2) The microcapsules isolated from the peritoneal cavity were cultured in DMEM (adding prepared hepatic parenchymal cells) culture medium (37°C, 5% CO 2 ) 2-3 months, the diameter of the cyst reaches 3-4mm.

[0106] 1.3. Evaluation of drug killing effect

[0107] 1) An experi...

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Abstract

The present invention relates to application of small molecular compound Sorafenib in treatment of hepatic echinococcosis, more specifically, the invention provides a use of the sorafenib compound in preparation of a composition or a preparation, and the composition or the preparation is used for (a) treatment of the hepatic echinococcosis and / or (b) treatment of alveolar echinococcosis. Compared with therapeutic drug albendazole in the prior art, the sorafenib has a stronger killing effect and is earlier and faster to take effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to the application of the anticancer small molecular compound sorafenib and its analogs in the treatment of liver echinococcosis. Background technique [0002] Hepatic hydatid disease is a common name for echinococcosis (Eechinococcus multilocularis), a zoonotic parasitic disease that seriously threatens human health and life caused by the larvae of Echinococcus multilocularis. Adult worms in the intestinal tract of dogs or foxes excrete infectious eggs to the environment (vegetables in the fields and rivers, etc.), and after being eaten by humans, enter the liver through the mesenteric vein to develop into larvae ( figure 1 ). [0003] There are many types of Echinococcus, currently in my country there are mainly Echinococcus guanluosus and E. multilocularis, and their larvae cause echinococcosis (also known as cystic hepatic cysts) respectively. Cystic echinococcosi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/44A61P33/10A01N47/30A01P1/00
Inventor 党志胜肖宁周晓农胡薇张颋徐斌沈海默陈军虎
Owner STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT