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A Flow Cytometer Realizing High Speed ​​and Wide Dynamic Range Pulse Signal Recovery

A flow cytometer and wide dynamic range technology, applied in the field of low-light detection and pulse processing, can solve problems such as errors and missing signal recovery, achieve high precision and avoid extraction errors

Active Publication Date: 2019-03-19
BEIJING INFORMATION SCI & TECH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the commonly used recovery method is to perform rectangular recovery on the signal under the threshold, but the inability to recover all missing signals will also introduce certain errors

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  • A Flow Cytometer Realizing High Speed ​​and Wide Dynamic Range Pulse Signal Recovery
  • A Flow Cytometer Realizing High Speed ​​and Wide Dynamic Range Pulse Signal Recovery
  • A Flow Cytometer Realizing High Speed ​​and Wide Dynamic Range Pulse Signal Recovery

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Embodiment Construction

[0027] Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. In the drawings, the same reference numerals represent the same or similar components, or the same or similar steps.

[0028] The objects and functions of the present invention and methods for achieving the objects and functions will be clarified by referring to the exemplary embodiments. However, the present invention is not limited to the exemplary embodiments disclosed below; it can be implemented in various forms. The essence of the description is only to help those skilled in the relevant art comprehensively understand the specific details of the present invention.

[0029] The present invention is described in detail in conjunction with schematic diagrams. When describing the embodiments of the present invention in detail, for the convenience of explanation, the cross-sectional view showing the structure of the device will not be partially enlarged acc...

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Abstract

The invention provides a flow cytometry capable of realizing high speed wide dynamic range pulse signal recovery. The flow cytometry comprises a sensor, an electric pulse signal conditioning unit, a base line recovery unit, an analog-digital conversion module, a pulse recovery unit and a parameter extraction module, wherein the sensor receives forward scattered light, side scattered light and multicolor fluorescence signals formed by microspheres through laser radiation, and completes photoelectric conversion to convert a light pulse signal into an electric pulse signal; the electric pulse signal conditioning unit amplifies, filters and performs other treatment on the electric pulse signal output by the sensor, and transmits the conditioned electric pulse signal to the subsequent base line recovery unit; and the base line recovery unit removes a direct-current component in the electric pulse signal according to the signal features of the electric pulse signal, recovers the base line of the electric pulse signal to be in proximity to the zero line and transmits the base line recovered electric pulse signal to the analog-digital conversion module.

Description

technical field [0001] The invention relates to the field of low-light detection and pulse processing of a flow cytometer, in particular to a flow cytometer device and method for realizing high-speed wide dynamic range pulse signal recovery. Background technique [0002] In the low-light detection system of flow cytometer, in the process of analog / digital conversion of electric pulse signal, it is usually necessary to set a threshold signal as the trigger signal of analog / digital conversion, that is, when the amplitude of electric pulse signal is lower than The A / D conversion operation is not performed when the threshold is reached, and the A / D conversion operation is started when the amplitude of the electrical pulse signal is not lower than the threshold. Due to the setting of the threshold value, the analog / digital conversion cannot be performed on all the electrical pulse signals, resulting in the loss of information of a part of the pulse signal lower than the threshold...

Claims

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Application Information

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IPC IPC(8): G01N15/14
CPCG01N15/1429
Inventor 祝连庆张文昌董明利娄小平郭阳宽刘超刘锋
Owner BEIJING INFORMATION SCI & TECH UNIV
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