A kind of fusion protein and its use for treating diseases
A technology of fusion protein and application, which is applied in the field of fusion protein and its treatment of diseases, and can solve problems such as complicated diagnosis, long course of treatment, and no medicine available
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Embodiment 1
[0155] In this example, the inventors prepared the fusion protein of interleukin-2 and diphtheria toxin (hereinafter referred to as fusion protein) according to the present invention. For issues such as the expression vector construction of the fusion protein of the present invention and the expression and purification of the fusion protein, refer to the paper (Structure / Function Analysis of the Transmembrane Domain of DAB389-Interleukin-2, an Interleukin-2 Receptor-targeted Fusion Toxin, The journal of biological chemistry, Vol.268, No.16, pp.12077-12062, 1993).
[0156] The cDNA gene sequence of the fusion protein in the present embodiment is as follows,
[0157]
[0158] The purified fusion protein was adjusted to a concentration of 150UG / ML for animal experiments. The experiment included two groups, the first group was the normal saline control group, and the second group was the fusion protein treatment group. Each group includes 12 cynomolgus macaques, about 4-6 yea...
Embodiment 2
[0159] Example 2 fusion protein can cause apoptosis
[0160] Laser confocal technology was used to detect and found that the treatment of fusion protein could cause the apoptosis of human lung epithelial cells A549 cells that had swallowed Mycobacterium tuberculosis ( figure 2 ), further capable of killing intracellular parasitic Mycobacterium tuberculosis.
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