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Targeting carbon nanotube drug delivery system, and preparation method and applications thereof

A delivery system and technology of carbon nanotubes, which can be used in pharmaceutical formulations, drug combinations, anti-tumor drugs, etc., and can solve problems such as low product yield and limited application of carbon nanotubes

Active Publication Date: 2017-04-05
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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Problems solved by technology

However, although the currently emerging modification methods have great application potential, the low product yield due to multi-step coupling reactions and purification processes greatly limits the application of carbon nanotubes in the biomedical field.

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  • Targeting carbon nanotube drug delivery system, and preparation method and applications thereof
  • Targeting carbon nanotube drug delivery system, and preparation method and applications thereof
  • Targeting carbon nanotube drug delivery system, and preparation method and applications thereof

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Embodiment Construction

[0065] Various terms and phrases used in the present invention have common meanings known to those skilled in the art. Even so, the present invention still hopes to explain and explain these terms and phrases in more detail again. If the terms and phrases mentioned have common meanings In case of inconsistency, the meaning expressed in the present invention shall prevail.

[0066] In the present invention, the term "carbon nanotube" has a well-known meaning in the art, which is described, for example, in Iijima S., Nature, 1991, 354:56.

[0067] In the present invention, the carbon nanotubes are single-walled carbon nanotubes or multi-walled carbon nanotubes or a mixture of the two in any proportion. In one embodiment of the present invention, the carbon nanotubes are single-walled carbon nanotubes.

[0068] The carbon nanotubes used in the present invention have a large number of functional groups, such as carboxyl, hydroxyl, etc., on their surface, or they are treated by ph...

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Abstract

The invention provides a targeting carbon nanotube drug delivery system, and a preparation method and applications thereof. The drug delivery system comprises a conjugate and a drug carrying carbon nanotube that is combined with the conjugate in a non-covalent mode; wherein the conjugate comprises a modifying material that can enhance the water solubility and biocompatibility of the drug delivery system and a targeting molecule that is combined with the modifying material in a covalent mode; and the drug carrying carbon nanotube is composed of carbon nanotubes and drug molecules that adsorb on the surface of the carbon nanotubes. One step modification technology is adopted, the problems on purification and yield caused by multi-step modification are avoided; at the same time, the carbon nanotube and drug delivery system are enable to have water solubility, biocompatibility, and multi-functions; the exocytosis of drug resistant tumor cells on drug molecules is effectively overcome, a novel strategy is provided for overcoming multi-drug resistance of tumor cells, and thus the provided drug delivery system has a wide application prospect in the field of drug resistant tumor treatment.

Description

technical field [0001] The invention relates to the field of tumor targeting therapy, in particular to a targeted carbon nanotube drug delivery system, its preparation method and application. Background technique [0002] Tumor multidrug resistance (MDR) refers to the cross-resistance of tumor cells to other drugs that have nothing to do with its structure and have different mechanisms of action while being resistant to one chemotherapeutic drug. Obstacles are also the main reason for the failure of chemotherapy. More than 90% of cancer patients chemotherapy failure and tumor recurrence are related to tumor multidrug resistance. There are many mechanisms that cause MDR, the most typical of which is due to the overexpression of the ABC (ATP binding cassette) transporter family (especially P-glycoprotein), which makes anti-tumor drugs effluxed by drug-resistant tumor cells, thereby reducing the Drug concentration in tumor cells. This MDR caused by P-glycoprotein often exist...

Claims

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Application Information

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IPC IPC(8): A61K47/61A61K47/54A61K47/52A61K31/704A61P35/00A61P35/02
CPCA61K31/704
Inventor 张英鸽姚红娟孙岚刘岩
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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