Traditional Chinese medicine composition having effect of inhibiting tumor-related cytokines and use thereof

Abstract

The invention provides a traditional Chinese medicine composition having an effect of inhibiting tumor-related cytokines. The traditional Chinese medicine composition is prepared from 12 to 18 portions by weight of radix astragali, 8 to 12 portions by weight of glossy privet fruit, 1 to 2 portions by weight of American ginseng and 1 to 2 portions by weight of licorice root. The invention also provides a use of the traditional Chinese medicine composition in inhibition of tumor-related cytokines. The cytokines comprise PD-L1, IL-13, IL-1 and TNF. The invention also provides a method for preparing the traditional Chinese medicine composition. Through use of licorice root and American ginseng based on the traditional Chinese medicines of radix astragali and glossy privet fruit, expression of PD-L1 in tumor cells is directly inhibited and expression of cytokines such as IL-13, IL-1 and TNF is adjusted from the upstream so that an immune system is adjusted in a cell level and in a liquid level, immune functions are recovered, development of tumors is inhibited and patient survival time is prolonged. Compared with the existing monoclonal antibody, the traditional Chinese medicine composition has a lower cost and higher safety.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition capable of inhibiting tumor-related cytokines and its application. Background technique [0002] PD-L1 is "programmed cell death-ligand 1, the English name is programmed cell death-Ligand 1, which is the first type of transmembrane protein with a size of 40kDa. Under normal circumstances, the immune system will respond to foreign substances gathered in lymph nodes or spleen. The antigen reacts and promotes the proliferation of antigen-specific T cells. The programmed cell death receptor-1 (PD-1) binds to the programmed cell death-ligand 1 (PD-L1) and can transmit inhibitory signals. Decreases the proliferation of T cells. [0003] One way for tumor cells to evade T cell destruction is by producing PD-L1 on their surface. When PD-1 on the surface of immune cell T cells recognizes PD-L1, it can transmit inhibitory si...

AI Technical Summary

Problems solved by technology

However, in the existing research including this composition, there is no report on the inhibition of PD-L1 by traditional Chinese medicine composition, especially the research on the inhibition of PD-L1 by using astragalus as the main raw material

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