Ajuga nipponensis makino active substance extraction method

A technology of Prunella vulgaris and its extraction method, which is applied in the field of chemical extraction and separation, can solve the problems of insufficient utilization of Chinese medicinal materials, lack of extraction and purification methods, etc., and achieve the effects of reducing extraction cost, improving extraction efficiency, and low cost

Active Publication Date: 2017-06-27
HUANGSHAN TIANMU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Prunella vulgaris contains chemical components such as neocrotane terpenoids, flavonoids and steroids, from which effective components such as luteolin, crotane diterpene and calixasterone can be extracted, but due to the lack of high-efficiency Extraction and purification methods, this resource-rich Chinese medicinal material has not been fully utilized

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for extracting effective substances from Prunella vulgaris, comprising pretreatment of Prunella vulgaris, microwave sterilization, solvent extraction, separation and purification, and the specific steps are as follows:

[0023] Pretreatment: Select 6kg of fresh Prunella vulgaris harvested from September to October, preferably those with thin stems, flexible texture and obvious four edges. Rush to wash: put Prunella vulgaris into clean water, and take it out immediately after quick washing, so as to avoid the active ingredients in the medicinal material being dissolved in water and lost with water. Cut into sections: Cut the cleaned Prunella vulgaris into small sections of 0.6-0.9cm, and dry until the water content is 8%, so as to facilitate subsequent processing.

[0024] Microwave Sterilization: Put it into a microwave sterilizer, spread it with a thickness of 4-6cm, and sterilize it at a microwave frequency of 2200MHz for 50s. After the sterilization is compl...

Embodiment 2

[0029] A method for extracting effective substances from Prunella vulgaris, comprising pretreatment of Prunella vulgaris, microwave sterilization, solvent extraction, separation and purification, and the specific steps are as follows:

[0030] Pretreatment: Select 5kg of fresh Prunella vulgaris harvested from September to October, preferably those with thin stems, flexible texture and obvious four edges. Rush to wash: put Prunella vulgaris into clean water, take it out immediately after quick washing. Cut into sections: Cut the cleaned Prunella vulgaris into small sections of 0.6-0.9cm, and dry until the water content is 7%, so as to facilitate subsequent processing.

[0031] Microwave sterilization: Put it into a microwave sterilizer, spread it with a thickness of 4cm, and sterilize it at a microwave frequency of 2000MHz for 40s. After the sterilization is completed, let it cool naturally. Under the condition that the temperature is -50--80°C, the medicinal materials are cru...

Embodiment 3

[0036] A method for extracting effective substances from Prunella vulgaris, comprising pretreatment of Prunella vulgaris, microwave sterilization, solvent extraction, separation and purification, and the specific steps are as follows:

[0037]Pretreatment: Select 8kg of fresh Prunella vulgaris harvested from September to October, preferably those with thin stems, flexible texture and obvious four edges. Rush to wash: put Prunella vulgaris into clean water, take it out immediately after quick washing. Cut into sections: Cut the cleaned Prunella vulgaris into small sections of 0.6-0.9cm, and dry until the water content is 9%, so as to facilitate subsequent processing.

[0038] Microwave sterilization: Put it into a microwave sterilizer, spread it with a thickness of 5cm, and sterilize it at a microwave frequency of 2400MHz for 50s. After the sterilization is completed, let it cool naturally. After the temperature drops to room temperature, carry out low-temperature crushing. Un...

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Abstract

The invention belongs to the technical field of chemical extraction and separation and aims at providing an efficient ajuga nipponensis makino active substance extraction method. According to the adopted technical scheme, the extraction method comprises the steps of ajuga nipponensis makino pretreatment, microwave sterilization, solvent extraction and separating purification, wherein the pretreatment includes medicinal material selection, washing and cutting, medicinal materials can be thoroughly cleaned and plant cell walls can be broken through microwave sterilization, and luteolin, clerodane diterpenoid and cyasterone are separated and purified by adopting a column chromatography, a macroporous resin method and a high performance liquid chromatography respectively. The efficient ajuga nipponensis makino active substance extraction method is low in cost and high in efficiency and can fully extract a variety of effectively ingredients in ajuga nipponensis makino.

Description

technical field [0001] The invention belongs to the technical field of chemical extraction and separation, and in particular relates to a method for extracting effective substances from Prunella vulgaris. Background technique [0002] Prunella vulgaris, also known as Golden Sore Grass and Prunella sinensis, is the whole plant of the Lamiaceae plant. The taste of the medicine is bitter and sweet, and the property of the medicine is cold. It has the functions of relieving cough and reducing phlegm, clearing heat, cooling blood, reducing swelling, and detoxifying. It grows on roadsides, river banks, at the foot of mountains, and wastelands, and is distributed all over the country. It is a common Chinese herbal medicine. [0003] Prunella vulgaris contains chemical components such as neocrotane terpenoids, flavonoids and steroids, from which effective components such as luteolin, crotane diterpene and calixansterone can be extracted, but due to the lack of high-efficiency Extr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40C07J17/00A61K36/53A61P11/00
CPCA61K36/53C07D311/30C07D311/40C07J17/00
Inventor 汪培钧程传付汪海晖许建国汪世元
Owner HUANGSHAN TIANMU PHARMA
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