Novel application of fructus tribuli TTS-12, traditional Chinese medicine gel for inhibiting trichophyton mentagrophytes and preparation method of traditional Chinese medicine gel

A technology of Trichophyton mentagrophytes and TTS-12, which is applied in the field of traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and its preparation, can solve the problem of low antibacterial concentration, poor antibacterial effect, and antibacterial effect of Tribulus TTS-12. Unpredictable effects and other problems, to achieve the effect of simple components, easy to clean, and good anti-fungal infection

Active Publication Date: 2017-07-07
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tribulus TTS-12 is a spirosterane-type saponin extracted from the whole plant of Tribulus terrestris. Studies have found that Tribulus TTS-12 has a strong inhibitory effect on Candida albicans and Cryptococcus neoformans, with MIC values ​​of 1 μg / mL and 2μg / mL, however, the antibacterial effect on Sporothrix schenckii, which is also a fungus, is poor, and the minimum inhibitory concentration is greater than 128μg / mL
Therefore, the antibacterial effect of Tribulus TTS-12 against different strains is unpredictable

Method used

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  • Novel application of fructus tribuli TTS-12, traditional Chinese medicine gel for inhibiting trichophyton mentagrophytes and preparation method of traditional Chinese medicine gel
  • Novel application of fructus tribuli TTS-12, traditional Chinese medicine gel for inhibiting trichophyton mentagrophytes and preparation method of traditional Chinese medicine gel
  • Novel application of fructus tribuli TTS-12, traditional Chinese medicine gel for inhibiting trichophyton mentagrophytes and preparation method of traditional Chinese medicine gel

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, Chinese medicine gel 1

[0030] A traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes, which consists of the following components in terms of mass percentage: Tribulus TTS-12 0.8%, Carbomer 940 1.5%, Glycerin 15%, TTS-12 latent solvent 29.2% , triethanolamine 2.025%, ethylparaben 0.03%, and the balance is distilled water; wherein, the TTS-12 latent solvent is composed of 70% ethanol and propylene glycol in a mass ratio of 3:7.

Embodiment 2

[0031] Embodiment 2, Chinese medicine gel 2

[0032] A traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes, which consists of the following components in terms of mass percentage: Tribulus TTS-12 1%, Carbomer 940 1.5%, Glycerin 5%, TTS-12 latent solvent 29% , triethanolamine 2.025%, ethylparaben 0.03%, and the balance is distilled water; wherein, the TTS-12 latent solvent is composed of 70% ethanol and propylene glycol in a mass ratio of 3:7.

Embodiment 3

[0033] Embodiment 3, Chinese medicine gel 3

[0034] A traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes, which consists of the following components in terms of mass percentage: Tribulus TTS-12 0.5%, Carbomer 940 1%, Glycerin 15%, TTS-12 latent solvent 29.5% , triethanolamine 1.35%, ethylparaben 0.03%, and the balance is distilled water; wherein, the TTS-12 latent solvent is composed of 70% ethanol and propylene glycol in a mass ratio of 3:7.

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Abstract

The invention discloses novel application of fructus tribuli TTS-12, a traditional Chinese medicine gel for inhibiting trichophyton mentagrophytes and a preparation method of the traditional Chinese medicine gel. As for the traditional Chinese medicine gel with the fructus tribuli TTS-12 as a single main drug, the in vitro antibacterial activity is remarkably higher than that of a commercially available bifonazole gel, the in vivo guinea pig anti-infection curative effect is equal to that of a commercially available terbinafine hydrochloride cream, and the traditional Chinese medicine gel takes good anti-fungal infection action. The traditional Chinese medicine gel is simple and available in components, low in cost, good in comfort degree after being coated, liable to clean and more suitable for private infection sites; and the prepared gel has good in vitro release effect and can reach good effect in resisting the trichophyton mentagrophytes.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and more specifically relates to a new application of Tribulus terrestris TTS-12, a traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and a preparation method thereof. Background technique [0002] Trichophyton mentagrophytes, also known as gypsum-like Trichophyton, is one of the more common and most easily isolated dermatophytes from humans and animals. It can not only cause tinea corporis, tinea manus, pedis, Ringworm diseases such as onychomycosis and tinea capitis can also cause deep infections such as pyogenic tinea, abscess and granuloma. Ringworm is extremely stubborn, and recurrence and reinfection often occur, and existing medicines are difficult to achieve a radical cure. [0003] Taking tinea corporis as an example, its treatment is based on western medicine, and the commonly used western medicine antibacterial drugs include antifungal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/06A61K47/32A61P31/10A61P31/02
CPCA61K9/0014A61K9/06A61K31/7048A61K47/32
Inventor 吴新荣谭翠雯彭海莹陈龙浩黄木土
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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