Application of indomethacin in preparation of drugs for preventing and treating cancers

A technology of indomethacin and cancer, which is applied in the field of medicine to achieve the effect of improving recurrence prevention, inhibiting tumor growth, and reducing tumors in mice

Inactive Publication Date: 2017-08-01
CHINA-US (HENAN) HORMEL CANCER INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of indomethacin in preparation of drugs for preventing and treating cancers
  • Application of indomethacin in preparation of drugs for preventing and treating cancers
  • Application of indomethacin in preparation of drugs for preventing and treating cancers

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Embodiment

[0034] Materials and Methods

[0035] 1 material

[0036] 1.1 Tumor tissue

[0037]The present invention uses 3 cases of human esophageal cancer tissue samples. The numbers of the three models are EG37, HEG5 and HEG18. EG37 was obtained from the First Affiliated Hospital of Zhengzhou University, Henan Province, male, 69 years old. The postoperative pathological section showed: poorly differentiated, no lymph node metastasis, and pathological stage: T2N0M0Ⅱa. HEG5 was obtained from Henan Cancer Hospital, male, 63 years old, esophageal squamous cell carcinoma, poorly differentiated. HEG18 was obtained from Henan Cancer Hospital, female, 73 years old, poorly differentiated squamous cell carcinoma of the esophagus, invading the outer membrane. The EG37 model used in the present invention is the 6th generation, the HEG5 is the 3rd generation, and the HEG18 is the 5th generation.

[0038] 1.2 4T1 breast cancer cells

[0039] 4T1 breast cancer cells were purchased from ATCC ce...

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Abstract

The invention relates to application of indomethacin in preparation of drugs for preventing and treating cancers. Molecular formula of the indomethacin is C19H16ClNO4 and molecular weight of the indomethacin is 357.79. Significant effects of indomethacin on prevention of an esophagus cancer in a humanized transplantation tumor model (PDX) and a breast cancer in a mouse 4T1 breast cancer cell line transplanted model are verified. According to the application of the indomethacin in the preparation of the drugs for preventing and treating the cancers, the indomethacin is used for treating a humanized esophagus cancer tumor and a breast cancer cell transplantation mouse correspondingly, and when gross tumor volume of a control group is up to 1500 cubic millimeters or above, a test is finished. Test discoveries are that: compared with the control group, the gross tumor volume of the indomethacin-treated mice is significantly smaller, and a significant statistical difference is existent, indicating that the indomethacin has significant effects on preventing the esophagus cancer and the breast cancer. The esophagus cancer and the breast cancer can be prevented and treated clinically by taking the indomethacin by patients.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of indomethacin in the preparation of drugs for preventing and treating cancer, in particular to the application of indomethacin as a drug for preventing and treating esophageal cancer and breast cancer in clinical treatment. Background technique [0002] Cancer has become the first cause of death in China and is a serious public health problem. According to statistics, esophageal cancer and breast cancer are also the most common types of cancer and the most common cause of cancer death in China. Esophageal cancer is a common malignant tumor disease. According to relevant statistics, the mortality rate of esophageal cancer ranks second in the mortality rate of malignant tumors in my country. Among them, esophageal cancer is relatively serious in Hebei Province, accounting for 10% of the mortality rate of malignant tumors. first. Breast cancer is the most commo...

Claims

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Application Information

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IPC IPC(8): A61K31/405A61P35/00A61P35/04
CPCA61K31/405
Inventor 董子钢刘康栋刘方方
Owner CHINA-US (HENAN) HORMEL CANCER INST
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