Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of indomethacin in preparation of drugs for preventing and treating cancers

A technology of indomethacin and cancer, which is applied in the field of medicine to achieve the effect of improving recurrence prevention, inhibiting tumor growth, and reducing tumors in mice

Inactive Publication Date: 2017-08-01
CHINA-US (HENAN) HORMEL CANCER INST
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been no studies addressing the effects of indomethacin on cancer, especially esophageal or breast cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of indomethacin in preparation of drugs for preventing and treating cancers
  • Application of indomethacin in preparation of drugs for preventing and treating cancers
  • Application of indomethacin in preparation of drugs for preventing and treating cancers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0034] Materials and Methods

[0035] 1 material

[0036] 1.1 Tumor tissue

[0037]The present invention uses 3 cases of human esophageal cancer tissue samples. The numbers of the three models are EG37, HEG5 and HEG18. EG37 was obtained from the First Affiliated Hospital of Zhengzhou University, Henan Province, male, 69 years old. The postoperative pathological section showed: poorly differentiated, no lymph node metastasis, and pathological stage: T2N0M0Ⅱa. HEG5 was obtained from Henan Cancer Hospital, male, 63 years old, esophageal squamous cell carcinoma, poorly differentiated. HEG18 was obtained from Henan Cancer Hospital, female, 73 years old, poorly differentiated squamous cell carcinoma of the esophagus, invading the outer membrane. The EG37 model used in the present invention is the 6th generation, the HEG5 is the 3rd generation, and the HEG18 is the 5th generation.

[0038] 1.2 4T1 breast cancer cells

[0039] 4T1 breast cancer cells were purchased from ATCC ce...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of indomethacin in preparation of drugs for preventing and treating cancers. Molecular formula of the indomethacin is C19H16ClNO4 and molecular weight of the indomethacin is 357.79. Significant effects of indomethacin on prevention of an esophagus cancer in a humanized transplantation tumor model (PDX) and a breast cancer in a mouse 4T1 breast cancer cell line transplanted model are verified. According to the application of the indomethacin in the preparation of the drugs for preventing and treating the cancers, the indomethacin is used for treating a humanized esophagus cancer tumor and a breast cancer cell transplantation mouse correspondingly, and when gross tumor volume of a control group is up to 1500 cubic millimeters or above, a test is finished. Test discoveries are that: compared with the control group, the gross tumor volume of the indomethacin-treated mice is significantly smaller, and a significant statistical difference is existent, indicating that the indomethacin has significant effects on preventing the esophagus cancer and the breast cancer. The esophagus cancer and the breast cancer can be prevented and treated clinically by taking the indomethacin by patients.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of indomethacin in the preparation of drugs for preventing and treating cancer, in particular to the application of indomethacin as a drug for preventing and treating esophageal cancer and breast cancer in clinical treatment. Background technique [0002] Cancer has become the first cause of death in China and is a serious public health problem. According to statistics, esophageal cancer and breast cancer are also the most common types of cancer and the most common cause of cancer death in China. Esophageal cancer is a common malignant tumor disease. According to relevant statistics, the mortality rate of esophageal cancer ranks second in the mortality rate of malignant tumors in my country. Among them, esophageal cancer is relatively serious in Hebei Province, accounting for 10% of the mortality rate of malignant tumors. first. Breast cancer is the most commo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/405A61P35/00A61P35/04
CPCA61K31/405
Inventor 董子钢刘康栋刘方方
Owner CHINA-US (HENAN) HORMEL CANCER INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com