Aeromonas salmonicida phage, bactericidal composition containing aeromonas salmonicida phage and application of aeromonas salmonicida phage and bactericidal composition

A technology for killing Aeromonas salmon and bacteriophage, applied in the field of bactericidal compositions and killing Aeromonas salmon phage, can solve the problems of high dosage, evolutionary phage, narrow host spectrum, etc.

Active Publication Date: 2017-08-08
SHENZHEN INST OF ADVANCED TECH
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  • Abstract
  • Description
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Problems solved by technology

However, as far as the current application of single phage therapy is concerned, some potential disadvantages gradually appear in the application process, such as a narrow range of host spectrum that can be lysed, a high dose required to lyse a certain number of hosts, and hosts evolving phage resistance in a short period of time. sex etc.

Method used

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  • Aeromonas salmonicida phage, bactericidal composition containing aeromonas salmonicida phage and application of aeromonas salmonicida phage and bactericidal composition
  • Aeromonas salmonicida phage, bactericidal composition containing aeromonas salmonicida phage and application of aeromonas salmonicida phage and bactericidal composition
  • Aeromonas salmonicida phage, bactericidal composition containing aeromonas salmonicida phage and application of aeromonas salmonicida phage and bactericidal composition

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Embodiment

[0075] The embodiments of the present invention will be described in detail below with reference to the examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention and should not be regarded as limiting the scope of the present invention. If the specific conditions are not indicated in the examples, it is carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used without the manufacturer's indication are conventional products that can be purchased from the market.

[0076] The invention discloses the research on a phage cocktail preparation for efficiently cracking Atlantic salmon-killing Aeromonas. Taking a broad-spectrum drug-resistant pathogenic Aeromonas salmonicida isolated from the skin ulcerated muscle, liver and kidney of Atlantic salmon as the host, 10 fission phages were isolated from the water environment, and the lysis...

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Abstract

The invention relates to an aeromonas salmonicida phage, a bactericidal composition containing the aeromonas salmonicida phage and application of the aeromonas salmonicida phage and the bactericidal composition. The phage can rapidly inhibit the growth of Atlantic aeromonas salmonicida in a short time and inhibit the generation of resistance to the pathogenic bacterium phage. In addition, the bactericidal composition of the phage is safe and effective and is high in specificity, the production cost is low, and the defects of a single phage therapy in a pathogen control process are made up.

Description

technical field [0001] The present invention relates to the field of biotechnology, in particular, to the Aeromonas salmonicidal phage, a bactericidal composition comprising the same, and applications thereof. Background technique [0002] Aeromonas salmonicida is a Gram-negative bacillus belonging to the genus Aeromonas under the phylum Proteobacteria. It is widely distributed in the aquatic environment, especially in the intestinal tract of aquatic animals, and is responsible for the occurrence of salmonid trout. The main pathogenic bacteria of boils and ulcers. A. salmonicida has a wide host range and, in some cases, can cause a variety of infectious diseases in and outside the intestines of humans and animals. Under high-density farming conditions, due to the high lethality and morbidity of Aeromonas salmonicidal bacteria, this type of pathogen is considered to be one of the main causes of the explosive death of many aquatic animals. Trout caused very serious losses. ...

Claims

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Application Information

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IPC IPC(8): C12N7/00A61K35/76A61P31/04A61P17/02C12R1/92
CPCA61K35/76C12N7/00C12N2795/00021C12N2795/00032A61K2300/00Y02A50/30
Inventor 马迎飞陈玲袁盛建
Owner SHENZHEN INST OF ADVANCED TECH
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