Purposes of medical composition in preparation of medical composition used for treating skin itching

A pharmaceutical composition and a technology for itchy skin, which are applied in the directions of drug combinations, medical preparations containing active ingredients, and skin diseases, etc., can solve the problems of patients with immunosuppressive side effects, inability to relieve skin itching in a long-term or effective manner, and increased bleeding.

Inactive Publication Date: 2017-08-18
PHYTOHEALTH CORP
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Problems solved by technology

[0008] In other words, due to the various types of dialysis membranes used by kidney dialysis patients during dialysis, it is easy to cause different degrees of complement activation during dialysis, prompting the patient's mast cells and basophils to release histamine, which in turn causes the patient's itching symptoms
At present, drugs such as heparin are mainly used clinically to slow down the inflammatory reaction of patients undergoing dialysis, but long-term use of heparin can easily increase the risk of bleeding
In addition, Thalidomide (Thalidomide) is also used clinically to relieve itching in uremic kidney dialysis patients, but it will cause side effects of immunosuppression in patients
[0009] However, the above-mentioned drugs or treatment methods for soothing itchy skin cannot relieve the symptoms of itchy skin for a long time or effectively, and the degree of itchy skin can only be defined by the patient's self-rating

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  • Purposes of medical composition in preparation of medical composition used for treating skin itching
  • Purposes of medical composition in preparation of medical composition used for treating skin itching
  • Purposes of medical composition in preparation of medical composition used for treating skin itching

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Embodiment Construction

[0036] 1. The pharmaceutical composition of nalbufen hydrochloride inhibits the oxidative stress caused by activated neutrophils.

[0037] The oxidative stress generated by neutrophil NADPH oxidase (NADPH oxidase) will not only cause damage to surrounding tissues, but also further fully activate its own inflammatory response. Therefore, for the development of drugs for inflammatory diseases, neutrophil NADPH oxidation The enzyme (NADPH oxidase) is a very important therapeutic target. The superoxide free radicals generated by NADPH oxidase will be released into the cell by the membrane of phage or granules or directly outside the cell through the cell membrane, and the superoxide free radical will be decomposed into hydrogen peroxide (H 2 o 2 ), hydroxyl radical (OH . ), and hypochlorous acid (HOCl), these reactions have an important relationship with many inflammatory diseases. Current studies believe that the regulatory mechanisms and functions of NADPH oxidase on the plas...

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Abstract

The invention purposes of a medical composition in preparation of medical compositions used for treating skin itching and is characterized in that the medical composition contains effective dose of hydrochloric acid nalbuphine and excipients acceptable as medicines.

Description

technical field [0001] The invention provides the application of the drug for skin diseases in the preparation of a pharmaceutical composition for treating skin itching, wherein the pharmaceutical composition comprises an effective dose of nalbufen hydrochloride and pharmaceutically acceptable excipients. Background technique [0002] Inflammation plays an important role in maintaining the stability of physiological functions, and has a certain relationship with the occurrence of many chronic skin diseases. Proteases, reactive oxygen species precursors, cytokines and neutrophil extracellular traps (NETs) released by neutrophils and macrophages can not only eliminate microorganisms, but also cause damage to surrounding tissues . Studies in recent years have confirmed that neutrophils and macrophages not only have the ability of innate immunity, but also have the function of acquired immunity. Treatment with chemotherapy drugs, alone or in combination, can cause many serious...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K31/485A61P17/04
CPCA61K31/485
Inventor李伊俐郑建新
OwnerPHYTOHEALTH CORP