Isoflavone compound capable of improving comfort of cigarette suction throat as well as preparation method for isoflavone compound and application of isoflavone compound

A technology of isoflavones, compounds, applied in the field of phytochemistry

Active Publication Date: 2017-09-01
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Adding the compounds of the present invention to cigarette filters can significantly i

Method used

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  • Isoflavone compound capable of improving comfort of cigarette suction throat as well as preparation method for isoflavone compound and application of isoflavone compound
  • Isoflavone compound capable of improving comfort of cigarette suction throat as well as preparation method for isoflavone compound and application of isoflavone compound
  • Isoflavone compound capable of improving comfort of cigarette suction throat as well as preparation method for isoflavone compound and application of isoflavone compound

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preparation example Construction

[0045] The preparation method of the isoflavone compounds of the present invention is prepared by taking kudzu root as raw material, extracting from extract, extracting with organic solvent, decolorizing MCI, silica gel column chromatography and high performance liquid chromatography, specifically:

[0046] A. Extraction of extract: pulverize kudzu root to 20-40 mesh, use solvent ultrasonic extraction for 2-5 times, the quality of the extraction solvent used each time is 2-4 times of kudzu root mass, each time for 30-60 minutes, combine the extracts And filtered, the filtrate was concentrated under reduced pressure until the precipitation was just observed by the naked eye, left to stand for 3 to 5 hours, and the precipitate was filtered off, and then the obtained filtrate was concentrated into extract a;

[0047] B. Organic solvent extraction: add water with a weight 1 to 2 times the weight of the extract a to the extract a, then extract 3 to 5 times with an organic solvent, e...

Embodiment 1

[0058] A, medicinal extract extraction: Pueraria lobata root is pulverized to 20 meshes, is extracted 2 times with solvent ultrasound, the quality of extraction solvent used at every turn is 2 times of Radix Puerariae quality, each time 30 minutes, merges extract and filters, and filtrate is concentrated under reduced pressure to It was observed with the naked eye that there was just a precipitate, and it was left to stand for 3 hours, and the precipitate was filtered off, and then the obtained filtrate was concentrated into extract a;

[0059] B, organic solvent extraction: in medicinal extract a, add the water that weight is 1 times of medicinal extract a weight, then extract 3 times with organic solvent, the volume of organic solvent used at every turn is identical with water volume, merge organic solvent extraction phase, Afterwards, the combined organic solvent extraction phases were concentrated under reduced pressure into extract b;

[0060] C. MCI decolorization: add p...

Embodiment 2

[0065] A, medicinal extract extraction: Pueraria lobata root is crushed to 40 orders, and the quality of extracting solvent used at every turn is 4 times of Pueraria lobata mass, and each time 60 minutes, combine extract and filter, and filtrate is concentrated under reduced pressure to It was observed with the naked eye that there was just a precipitate, and it was left to stand for 5 hours, and the precipitate was filtered off, and then the obtained filtrate was concentrated into extract a;

[0066] B, organic solvent extraction: in medicinal extract a, add the water that weight is 2 times of medicinal extract a weight, then extract 5 times with organic solvent, the volume of organic solvent used at every turn is identical with water volume, merge organic solvent extraction phase, Afterwards, the combined organic solvent extraction phases were concentrated under reduced pressure into extract b;

[0067] C, MCI decolorization: add pure methanol that is 5 times the weight of t...

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Abstract

The invention discloses an isoflavone compound capable of improving comfort of a cigarette suction throat as well as a preparation method for the isoflavone compound and application of the isoflavone compound, and belongs to the technical field of plant chemical technology. The compound is separated from traditional Chinese medicine radix pueraiae, a molecular formula of the compound is C18H14O5, and the compound is named as 7-acetyl-4'-hydroxyl-6-methoxyl-isoflavone; a structural formula of the compound as shown in formula (I): the formula (I) is described in the description. A preparation method for the isoflavone compound comprises the following steps: taking the traditional Chinese medicine radix pueraiae as a raw material, performing extract extraction, performing organic solvent extraction, performing MCI discoloring, performing column chromatography on silica gel and performing efficient liquid-phase chromatographic separation. The compound is added into a cigarette filter tip, so that the comfort of the cigarette suction throat can be improved, and therefore, the compound has the obvious throat clearing effect.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to an isoflavone compound extracted for the first time from Pueraria lobata, a Chinese medicinal material, its preparation method and application. The compound has the effect of significantly improving the throat comfort of cigarette smoking, and can be used as a cigarette mouthpiece additive to improve the smoking quality of cigarettes. Background technique [0002] Pueraria lobata is the dried root of the leguminous plant Pueraria mirifica, commonly known as Pueraria mirifica. Excavated in autumn and winter, cut into thick slices or small pieces while fresh; dry. Sweet, pungent, cool. It has the functions of relieving muscle and reducing fever, clearing rash, promoting body fluid and quenching thirst, promoting yang and relieving diarrhea. It is often used for superficial syndromes of fever, stiff neck and back pain, opaque measles, fever and thirst, yin defi...

Claims

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Application Information

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IPC IPC(8): C07D311/36C07D311/40A24D3/14
CPCA24D3/14C07D311/36C07D311/40
Inventor 王晓晖陈章玉李晶杨叶昆陈建华李干鹏王明锋者为倪朝敏吴海燕周敏徐济仓杨光宇胡秋芬
Owner CHINA TOBACCO YUNNAN IND
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