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Traditional Chinese medicine compound preparation for treating diabetes as well as preparation method and application thereof

A compound preparation and diabetes technology, which is applied in the fields of medical formula, urinary system diseases, medical preparations containing active ingredients, etc., can solve the problems of no report on the mechanism of hypoglycemic action, lack of scientific support, etc., and reach the level of traditional Chinese medicine The distribution ratio is scientific and reasonable, the effect of improving insulin sensitivity index and high content of active ingredients

Active Publication Date: 2017-09-29
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Astragalus, mulberry leaf, mulberry and lotus leaf, the prescription Qisang Jiangtang Fang, which is a combination of four traditional Chinese medicines, has shown a good hypoglycemic effect as a folk prescription, but it lacks scientific support, and the specific hypoglycemic mechanism has not been found. any reports

Method used

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  • Traditional Chinese medicine compound preparation for treating diabetes as well as preparation method and application thereof
  • Traditional Chinese medicine compound preparation for treating diabetes as well as preparation method and application thereof
  • Traditional Chinese medicine compound preparation for treating diabetes as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Formula (in parts by weight):

[0028] 12 parts of astragalus, 12 parts of mulberry, 10 parts of mulberry leaves, 10 parts of lotus leaves

[0029] 2, preparation method, comprises the following steps:

[0030] (1) Take 12 parts of astragalus, 12 parts of mulberry, 10 parts of mulberry leaves, and 10 parts of lotus leaves, decoct twice with 10 times the amount of water, decoct for 40 minutes for the first time, and 30 minutes for the second time, and combine The decocting solution is filtered and concentrated to obtain a concentrated solution for subsequent use;

[0031] (2) Get 12 parts of astragalus, 12 parts of mulberry fruit, 10 parts of mulberry leaves, and 10 parts of lotus leaves, and use 8 times the concentration of 60% ethanol to reflux extract twice, each time for 1 hour, combine the extracts, and decompress Concentrate to obtain a concentrated solution for subsequent use;

[0032] (3) Mix the concentrated solution obtained in step (1) and step (2) evenl...

Embodiment 2

[0034] 1. Formula (in parts by weight):

[0035] 12 parts of astragalus, 12 parts of mulberry, 10 parts of mulberry leaves, 10 parts of lotus leaves

[0036] 2, preparation method, comprises the following steps:

[0037] (1) Take 12 parts of astragalus, 12 parts of mulberry, 10 parts of mulberry leaves, and 10 parts of lotus leaves, decoct twice with 10 times the amount of water, decoct for 40 minutes for the first time, and 30 minutes for the second time, and combine The decocting solution is filtered and concentrated to obtain a concentrated solution for subsequent use;

[0038] (2) Get 12 parts of astragalus, 12 parts of mulberry fruit, 10 parts of mulberry leaves, and 10 parts of lotus leaves, and use 8 times the concentration of 60% ethanol to reflux extract twice, each time for 1 hour, combine the extracts, and decompress Concentrate to obtain a concentrated solution for subsequent use;

[0039] (3) Add appropriate amount of starch and xylitol to the concentrated solu...

Embodiment 3

[0041] 1. Formula (in parts by weight):

[0042] 12 parts of astragalus, 12 parts of mulberry, 10 parts of mulberry leaves, 10 parts of lotus leaves

[0043] 2, preparation method, comprises the following steps:

[0044] (1) Take 12 parts of astragalus, 12 parts of mulberry, 10 parts of mulberry leaves, and 10 parts of lotus leaves, decoct twice with 10 times the amount of water, decoct for 40 minutes for the first time, and 30 minutes for the second time, and combine The decocting solution is filtered and concentrated to obtain a concentrated solution for subsequent use;

[0045] (2) Get 12 parts of astragalus, 12 parts of mulberry fruit, 10 parts of mulberry leaves, and 10 parts of lotus leaves, and use 8 times the concentration of 60% ethanol to reflux extract twice, each time for 1 hour, combine the extracts, and decompress Concentrate to obtain a concentrated solution for subsequent use;

[0046] (3) Add appropriate amount of starch and xylitol to the concentrated solu...

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Abstract

The invention relates to a traditional Chinese medicine compound preparation for treating diabetes as well as a preparation method and application thereof. The traditional Chinese medicine compound preparation is prepared from the following raw materials in parts by weight: 6-18 parts of astragalus, 6-18 parts of mulberries, 5-15 parts of folium mori and 5-15 parts of lotus leaves. The preparation method of the traditional Chinese medicine compound preparation comprises the following steps: decocting, filtering and concentrating so as to obtain a concentrated solution for later use; extracting and performing vacuum concentration so as to obtain a concentrated solution for later use; and preparing the decocted concentrated solution and the extracted concentrated solution as well as pharmaceutically acceptable carriers into oral liquid, granules, capsules, tablets and other dosage forms. Due to the multi-link and multi-target comprehensive effects, the traditional Chinese medicine compound preparation provided by the invention achieves the aims of lowering the blood sugar and blood fat and content of BUN and SCr, reducing expressions of NF-kB and ICAM-1 in renal tissues, improving the insulin sensitivity index and finally improving the diabetic renal functions in the aspect of treating diabetes.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a compound traditional Chinese medicine preparation for treating diabetes and its preparation method and application. Background technique [0002] In recent years, with changes in various factors such as the economy, environment, and lifestyle, the prevalence of diabetes has shown an accelerated upward trend. Currently, more than 100 million people in China suffer from diabetes. The disease can occur at any age, and As the course of the disease prolongs, it will lead to complications of blood vessels, heart, kidneys and other organs. If active treatment measures are not taken in the early stage of diabetes, diabetic patients will not receive good treatment and management, and the number of diabetic patients in my country will increase significantly. This will bring heavy mental pressure and economic burden to the healthy development of our society...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/62A61P3/10A61P13/12
CPCA61K36/481A61K36/605A61K36/62A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 蒲秀瑛李海兵李浩文马建忠张伟杰李晓玥任菁刘璐马小龙续文君
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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