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Benzopyran compound and application thereof

A technology of benzopyran and compounds, which is applied in the field of application of benzopyran compounds and their anti-bacterial biofilm, can solve the problems of anti-bacterial biofilm drug application, etc., and achieve a strong inhibitory effect

Active Publication Date: 2017-09-29
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no antibacterial biofilm drugs have been used clinically.

Method used

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  • Benzopyran compound and application thereof
  • Benzopyran compound and application thereof
  • Benzopyran compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0027] This embodiment synthesizes the compound with the general formula shown in formula II:

[0028]

[0029] among them:

[0030] (1) There is only a benzene ring, that is, no substituent R;

[0031] (2) R=2-NO 2 ,4-NO 2 ,2-CN,4-CN,5-CN,4-OH,4-CH 3 ,3-F,4-F,3,5-2F,3,4,5-3F,4-Cl,3,4-2Cl,3-Br,4-Br.

[0032] The synthesis method is:

[0033] A: In a 250mL three-necked flask, mix an appropriate amount of 1,3-cyclohexanedione, malononitrile and aromatic aldehydes with different substituents in a 1:1:1 mole ratio and then heat to dissolve;

[0034] B: Add a catalytic amount of 4-dimethylaminopyridine and heat to reflux for 3-4 hours;

[0035] C: The solid precipitates out after cooling, filtered with suction, and the solid is recrystallized with absolute ethanol to obtain a pure product.

[0036] Structure Identification:

[0037] The molecular weight, structure and purity of the new series of pyran compounds synthesized above were identified using organic spectra such as mass spectrometry (MS...

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Abstract

The invention relates to a benzopyran compound and application thereof. The benzopyran compound has a structure formula shown in a formula I. The application is the application of the compound in preparing a biological membrane medicine for resisting the staphylococcus aureus. The formula I is shown in the description, wherein R is 3-F, 4-F, 3,5-2F, 3,4,5-3F, 4-C1, 3,4-2C1, 3-Br, and 4-Br.

Description

Technical field [0001] The invention relates to a new compound and its antibacterial application, in particular to a type of benzopyran compound and its antibacterial biofilm application. Background technique [0002] Pyran compounds are an important oxygen-containing heterocyclic compound. Many natural compounds such as coumarins, flavans, flavonoids, alkaloids, pterostil, etc. often appear in such structures, which have a wide range of characteristics and application values. The two rigid ring structures in the pyran compounds make it have strong fluorescence performance in the visible light range, and are well used in functional materials such as fluorescent probes, fluorescent whitening agents, fluorescent fuels, and so on. In addition, these compounds have good pharmacological and biological activities, such as antioxidant activity, anticoagulant, anti-tumor activity, etc., and are widely used in anticoagulants, anticancer drugs, antiallergic drugs and other medicaments. Hu...

Claims

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Application Information

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IPC IPC(8): C07D311/74A61P31/04A01P1/00
CPCC07D311/74
Inventor 李明凯张靳伟罗礼阳曲迪于轶泽李靖罗晓星
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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