Serum/plasma miRNA markers associated with type 2 diabetic retinopathy and their application

A technology for retinopathy and type 2 diabetes, applied in the fields of genetic engineering and clinical medicine, can solve the problems of inability to diagnose type 2 diabetic retinopathy at an early stage, and achieve the effects of early diagnosis, accurate quantification, and minimally invasive sampling.

Active Publication Date: 2021-01-08
SHENZHEN UNIV +1
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Problems solved by technology

[0010] The purpose of the embodiments of the present invention is to overcome the above-mentioned deficiencies of the prior art, and provide a serum / plasma miRNA marker related to type 2 diabetic retinopathy and its application, so as to solve the problem that the current inability to effectively treat type 2 diabetic retinopathy plays an early role. Diagnosing technical issues

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  • Serum/plasma miRNA markers associated with type 2 diabetic retinopathy and their application
  • Serum/plasma miRNA markers associated with type 2 diabetic retinopathy and their application
  • Serum/plasma miRNA markers associated with type 2 diabetic retinopathy and their application

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Embodiment Construction

[0025] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0026] In one aspect, the embodiments of the present invention provide a serum / plasma miRNA marker associated with type 2 diabetic retinopathy. The serum / plasma miRNA markers associated with type 2 diabetic retinopathy are hsa-let-7a-5p, hsa-miR-novel-chr5_15976, hsa-miR-28-3p, hsa-miR-20a-5p, hsa - one or a combination of two or more of miR-151a-5p, hsa-miR-148a-3p and hsa-miR-223-3p. It has been verified that these miRNA markers can effectively diagnose type 2 diabetic retinopathy, especially the diagnosis of early (stage I-II) type 2 diabetic retinopathy.

[0027] After further verification, a...

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Abstract

The present invention provides a serum / plasma miRNA marker related to type 2 diabetic retinopathy and use thereof. The serum / plasma miRNA marker related to the type 2 diabetic retinopathy is one or a combination of two of hsa-let-7a-5p, hsa-miR-novel-chr5_15976, hsa-miR-28-3p, has-miR-20a-5p, has-miR-151a-5p, has-miR-148a-3p and has-miR-223s-3p. The serum / plasma miRNA marker related to the type 2 diabetic retinopathy is stable and can be used to early assist to diagnose whether a diabetic patient is combined with DR, and the disease progression of the diabetic retinopathy patient can be dynamically monitored, and the serum / plasma miRNA marker can be used to prepare an early diagnosis product of type 2 diabetes and the diabetic retinopathy.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and clinical medicine, and relates to a serum / plasma miRNA marker related to type 2 diabetic retinopathy and an application thereof. Background technique [0002] Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar and based on insulin resistance and insufficient insulin secretion. Chronic major diseases that various countries and governments focus on prevention and control. Clinically, diabetes is divided into type 1 diabetes and type 2 diabetes; among them, type 2 diabetes accounts for more than 90% of diabetic patients. According to the 2007-2009 national epidemiological survey, the total prevalence of diabetes in the population over 20 years old in my country has reached 9.7%. What is even more shocking is that the 2010 National Diabetes Epidemiological Survey showed that the prevalence of diabetes had risen to 11.6%, and the prevalence of prediabetes was as hi...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/158C12Q2600/178
Inventor 梁真翟日洪丁静云高开屏王毅欣
Owner SHENZHEN UNIV
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