Gadolinium ion based zeolite metal organic frame material, and preparation method and application of material

A metal-organic framework and zeolite-type technology, which is applied in the field of zeolite-type metal-organic framework materials and their preparation, can solve problems such as temperature non-specific identification, and achieve the effects of wide application, high field relaxation rate, and simple preparation method

Inactive Publication Date: 2017-12-08
NANKAI UNIV
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Problems solved by technology

Studies have shown that these complexes are easily affected by the physiological environment, such as responding to some redox processes, enzyme-catalyzed processes, glucose and metal ions, resulting in non-specific recognition of temperature

Method used

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  • Gadolinium ion based zeolite metal organic frame material, and preparation method and application of material
  • Gadolinium ion based zeolite metal organic frame material, and preparation method and application of material
  • Gadolinium ion based zeolite metal organic frame material, and preparation method and application of material

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Embodiment

[0026] A zeolite-type metal-organic framework material based on gadolinium ions, the specific composition of which is [Gd 48 (NO 3 ) 48 (bpdc) 48 ]·G x , wherein bpdc is 2,2'-6,6'-pyridine dioic acid salt, G is a solvent molecule, the organic solvent is a mixture of methanol and chloroform, and the volume ratio of the two in the mixture is 1:1, x is the number of solvent molecules, x=150.

[0027] A preparation method of the zeolite-type metal-organic framework material based on gadolinium ions, comprising the following steps:

[0028] 1) Mix and boil 0.2mmol gadolinium nitrate and 0.2mmol 2,2'-6,6'-pyridinedioic acid, 5mL methanol and 5mL chloroform, and keep the temperature at 80°C for 2 days to obtain a white solid;

[0029] 2) The white solid obtained in the above step 1) was filtered, washed with 20 mL of methanol and chloroform, and dried at room temperature to obtain a white solid of a gadolinium ion-based zeolite metal organic framework;

[0030] 3) Grinding 50 m...

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Abstract

The invention relates to a gadolinium ion based zeolite metal organic frame material, and a preparation method and an application of the material. The material has a formula of [Gd48(NO3)48(bpdc)48]*Gx, wherein bpdc is 2,2'-6,6'-pyridine diacid salt; G is a solvent molecule; the organic solvent is a mixture of methanol and trichloromethane at a volume ratio of 1:1 or a mixture of alcohol and dichloromethane at a volume ratio of 1:1; x is solvent molecule quantity with a scope of greater than 1; and the prepared gadolinium ion based zeolite metal organic frame material is used for a thermal imaging technology as a nuclear magnetic contrast agent. The material has the advantages that the material prepared by the method shows a high highfield relaxation rate and temperature selectivity; the highfield relaxation rate is higher than that of a clinical contrast agent; the preparation method is simple; industrial amplification is easy; the treatment is simple; and the material is applicable to the common clinical nuclear magnetic imaging and hyperthermia physiotherapy imaging, good in compatibility and wide in application.

Description

technical field [0001] The invention relates to the field of nuclear magnetic resonance, in particular to a gadolinium ion-based zeolite metal organic framework material and a preparation method thereof. Background technique [0002] Heat treatment therapy requires precise measurement of temperature changes to manage and cure cancer. The prior art has great limitations in heat treatment treatment. Usually, temperature sensors such as thermocouples, thermal resistors or thermal probes need to be implanted in the body for temperature measurement, which not only causes pain to the patient, but also can only measure local temperature. [0003] Compared with the traditional temperature measurement method, the method of nuclear magnetic resonance can not only reduce the pain of the patient, but also provide spatial three-dimensional resolution, which has great advantages. Usually the treatment range of heat treatment is 41-45 degrees, and the temperature of healthy tissue is kep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00C08J3/28B82Y40/00A61K49/10
CPCC08G83/008A61K49/106B82Y40/00C08J3/28C08J2387/00
Inventor 师唯张时远程鹏
Owner NANKAI UNIV
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