Zeolite type metal organic frame material based on gadolinium ions and preparation method thereof

A metal-organic framework and zeolite-type technology, applied in the field of zeolite-type metal-organic framework materials and their preparation, can solve problems such as temperature non-specific identification, and achieve the effects of wide application, good material compatibility, and easy industrial amplification

Inactive Publication Date: 2016-12-14
NANKAI UNIV
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Problems solved by technology

Studies have shown that these complexes are easily affected by the physiological environment, such as responding to some redox processes, enzyme-catalyzed processes, glucose and metal ions, resulting in non-specific recognition of temperature

Method used

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  • Zeolite type metal organic frame material based on gadolinium ions and preparation method thereof
  • Zeolite type metal organic frame material based on gadolinium ions and preparation method thereof
  • Zeolite type metal organic frame material based on gadolinium ions and preparation method thereof

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Embodiment

[0026] A zeolite-type metal-organic framework material based on gadolinium ions, the specific composition of which is [Gd 48 (NO 3 ) 48 (bpdc) 48 ]·G x , wherein bpdc is 2,2'-6,6'-pyridine dioic acid salt, G is a solvent molecule, the organic solvent is a mixture of methanol and chloroform, and the volume ratio of the two in the mixture is 1:1, x is the number of solvent molecules, x=150.

[0027] A preparation method of the zeolite-type metal-organic framework material based on gadolinium ions, comprising the following steps:

[0028] 1) Mix and boil 0.2mmol gadolinium nitrate and 0.2mmol 2,2'-6,6'-pyridinedioic acid, 5mL methanol and 5mL chloroform, and keep the temperature at 80°C for 2 days to obtain a white solid;

[0029] 2) After filtering the above-mentioned white solid, washing with 20 mL of methanol and chloroform, and drying at room temperature, a white solid of a zeolite-type metal-organic framework material based on gadolinium ions was obtained;

[0030] 3) ...

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Abstract

The invention provides a zeolite type metal organic frame material based on gadolinium ions. The specific composition of the material is [Gd48(NO3)48(bpdc)48].Gx, wherein bpdc serves as 2,2'-6,6'-pyridine diacid salt, G is solvent molecules, an organic solvent is a mixture of methyl alcohol and trichloromethane or a mixture of ethyl alcohol and dichloromethane, the volume ratio of methyl alcohol to trichloromethane in the mixture and the volume ratio of ethyl alcohol to dichloromethane in the mixture is 1:1, x is the number of the solvent molecules, and is larger than 1; the prepared zeolite type metal organic frame material based on the gadolinium ions serves as a nuclear magnetism contract medium for the thermal imaging technology. The zeolite type metal organic frame material has the advantages that the material prepared through the method shows the high high-field relaxation rate larger than that of a clinical contract medium and temperature selectivity; the preparation method is simple, industrial enlargement is easy, treatment is simple, and the material is suitable for common clinical nuclear magnetism radiography and hyperthermia physiotherapy radiography, and is good in compatibility and wide in application range.

Description

technical field [0001] The invention relates to the field of nuclear magnetic resonance, in particular to a gadolinium ion-based zeolite metal organic framework material and a preparation method thereof. Background technique [0002] Heat treatment therapy requires precise measurement of temperature changes to manage and cure cancer. The prior art has great limitations in heat treatment treatment. Usually, temperature sensors such as thermocouples, thermal resistors or thermal probes need to be implanted in the body for temperature measurement, which not only causes pain to the patient, but also can only measure local temperature. [0003] Compared with the traditional temperature measurement method, the method of nuclear magnetic resonance can not only reduce the pain of the patient, but also provide spatial three-dimensional resolution, which has great advantages. Usually the treatment range of heat treatment is 41-45 degrees, and the temperature of healthy tissue is kep...

Claims

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Application Information

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IPC IPC(8): A61K49/10
CPCA61K49/106
Inventor 师唯张时远程鹏
Owner NANKAI UNIV
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