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Tripterygium glycoside and tripterine monomer effect-enhancing and toxicity-reducing matching methods

A technology of tripterygium polyglycosides and tripterygne, which is applied in the direction of medical formulas, medical preparations containing active ingredients, active ingredients of hydroxyl compounds, etc., can solve the problems of increasing triptolide and weakening the effect of cell apoptosis, etc., to achieve Effect of reducing pain and reducing side effects

Active Publication Date: 2017-12-15
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Problems solved by technology

Stephanie et al. also used cytotoxicity (apoptosis) and inhibition of NFκB transcription as the detection indicators to find that Ca 2+ Depletion significantly increased the binding of triptolide to the cell membrane, but weakened the effect of apoptosis, but did not affect the inhibition of NF-κB transcriptional function. It is speculated that triptolide includes at least two different pathways of action to affect cell function

Method used

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  • Tripterygium glycoside and tripterine monomer effect-enhancing and toxicity-reducing matching methods
  • Tripterygium glycoside and tripterine monomer effect-enhancing and toxicity-reducing matching methods
  • Tripterygium glycoside and tripterine monomer effect-enhancing and toxicity-reducing matching methods

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Embodiment

[0030] (1) Experimental materials and methods

[0031] 1. Materials

[0032] 1.1 Drug tripterygium glycosides tablets, prepared as a solution with 0.25% CMC-Na; resveratrol.

[0033] 1.2 Reagents 0.3% pentobarbital sodium, aspartate aminotransferase (AST), alanine aminotransferase (alkaline aminotransferase, ALT), creatinine (creatinine, CREA), blood urea nitrogen (blood urea Nitrogen, BUN), uric acid (uric acid, UA) and other kits.

[0034] 1.3 Animals There were 30 female healthy ICR mice (SPF), weighing about 20 g.

[0035] 1.4 Instrument Hitachi 7020 automatic biochemical analyzer (Hitachi); 2120i blood analyzer (Siemens); AG204-electronic analytical balance (Switzerland METTLER); MLS-3020 autoclave (Japan Sanyo).

[0036] 2 methods

[0037] 2.1 Animal grouping and administration 30 female mice were randomly divided into 3 groups, 10 in each group, respectively blank group (A, Normal), tripterygium glycosides group (B, TWP), tripterygium glycosides + resveratilla Th...

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Abstract

The invention relates to the field of traditional Chinese medicine and discloses tripterygium glycoside and tripterine monomer effect-enhancing and toxicity-reducing matching methods. Tripterygium glycoside or tripterine monomers are matched with resveratrol to be used as a medicine. Main components of tripterygium wilfordii, namely, tripterygium glycoside or tripterine, are matched with the resveratrol to play effect-enhancing and toxicity-reducing roles. The resveratrol can increase IC50 of the tripterine for enterocyte and decrease IC50 of the tripterine for basophilic leukemia cells; apoptosis of the tripterine-induced enterocyte can be reduced; resveratrol is further found to play related roles by activating Sirt protein. The use of the tripterygium wilfordii, the tripterygium glycoside and the tripterine can be greatly enlarged, side effects of clinical medication can be reduced, and pain of clinical patients can be relieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a method for synergizing and reducing toxicity of tripterygium wilfordii polyglycoside and tripterygium wilfordii monomer. Background technique [0002] Tripterygium wilfordii and its preparations not only have unique and almost irreplaceable curative effects on autoimmune diseases, but also have certain toxic and side effects. Therefore, they are one of the most widely used Chinese herbal medicines in clinical practice, and are also the most reported poisoning incidents and toxic and side effects. One of Chinese herbal medicine. [0003] Tripterygium wilfordii is known as "broken intestine grass" and has toxic and side effects of irritating the gastrointestinal tract. People who take the medicine often experience symptoms such as anorexia, nausea, vomiting, abdominal distension, and diarrhea, and sometimes gastrointestinal bleeding. The toxic and side effects of Trip...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K31/56A61K31/05A61P37/02
CPCA61K31/05A61K31/56A61K36/37A61K2300/00
Inventor 傅惠英寿旗扬石森林李园园范永升
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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