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A kind of tripterygium glycosides and tripterygium monomer synergistic and attenuated toxicity compatibility method

A technology of tripterygium glycosides and resveratrol, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, active ingredients of hydroxyl compounds, etc. Pain-reducing, side-effect reduction

Active Publication Date: 2021-02-26
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Stephanie et al. also used cytotoxicity (apoptosis) and inhibition of NFκB transcription as the detection indicators to find that Ca 2+ Depletion significantly increased the binding of triptolide to the cell membrane, but weakened the effect of apoptosis, but did not affect the inhibition of NF-κB transcriptional function. It is speculated that triptolide includes at least two different pathways of action to affect cell function

Method used

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  • A kind of tripterygium glycosides and tripterygium monomer synergistic and attenuated toxicity compatibility method
  • A kind of tripterygium glycosides and tripterygium monomer synergistic and attenuated toxicity compatibility method
  • A kind of tripterygium glycosides and tripterygium monomer synergistic and attenuated toxicity compatibility method

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Embodiment

[0030] (1) Experimental materials and methods

[0031] 1. Materials

[0032] 1.1 Drug Tripterygium glycosides tablets, made into solution with 0.25% CMC-Na; resveratrol.

[0033] 1.2 Reagents 0.3% pentobarbital sodium, aspartate aminotransferase (AST), alanine aminotransferase (alkaline aminotransferase, ALT), creatinine (creatinine, CREA), blood urea nitrogen (blood urea Nitrogen, BUN), uric acid (uric acid, UA) and other kits.

[0034] 1.3 Animals 30 female healthy ICR mice (SPF), weighing about 20g.

[0035] 1.4 Instruments Hitachi 7020 automatic biochemical analyzer (Hitachi); ADVIA® 2120i blood analyzer (Siemens); AG204-electronic analytical balance (Switzerland METTLER); MLS-3020 autoclave (Japan Sanyo).

[0036] 2 methods

[0037] 2.1 Animal grouping and administration 30 female mice were randomly divided into 3 groups, 10 in each group, respectively blank group (A, Normal), tripterygium glycosides group (B, TWP), tripterygium glycosides + resveratilla There was no...

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Abstract

The invention relates to the field of traditional Chinese medicine, and discloses a method for synergizing and attenuating toxicity of tripterygium glycosides and tripterygnee monomers, in which tripterygium polyglycosides or tripterygnee monomers are compatible with resveratrol as a medicine application. The technology of the present invention uses the tripterygium wilfordii main component tripterygium glycosides or tripterygium and resveratrol compatibility to play a synergistic and detoxifying effect. Resveratrol can increase the IC50 of tripteryne on intestinal epithelial cells, and reduce the IC50 of tripteryne on basophilic leukemia cells; it can reduce the apoptosis of intestinal epithelial cells induced by tripteryne; and further found that Veratrol-related effects work by activating Sirt protein. The invention can greatly expand the use of tripterygium wilfordii, tripterygium glycosides and tripterygium wilfordii, reduce the side effects of clinical medication, and reduce pain for clinical patients.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a method for synergizing and reducing toxicity of tripterygium wilfordii polyglycoside and tripterygium wilfordii monomer. Background technique [0002] Tripterygium wilfordii and its preparations not only have unique and almost irreplaceable curative effects on autoimmune diseases, but also have certain toxic and side effects. Therefore, they are one of the most widely used Chinese herbal medicines in clinical practice, and are also the most reported poisoning incidents and toxic and side effects. One of Chinese herbal medicine. [0003] Tripterygium wilfordii is known as "broken intestine grass" and has toxic and side effects of irritating the gastrointestinal tract. People who take the medicine often experience symptoms such as anorexia, nausea, vomiting, abdominal distension, and diarrhea, and sometimes gastrointestinal bleeding. The toxic and side effects of Trip...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61K36/37A61K31/56A61P37/02
CPCA61K31/05A61K31/56A61K36/37A61K2300/00
Inventor 傅惠英寿旗扬石森林李园园范永升
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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