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Traditional Chinese medicine composition used for anti-premature ovarian failure and relevant preparations thereof

A technology for premature ovarian failure and composition, which is applied in the preparation of said traditional Chinese medicine composition, anti-premature ovarian failure traditional Chinese medicine composition and related preparation fields, to achieve the effects of reasonable composition, increased protein expression, and increased ovarian weight

Inactive Publication Date: 2017-12-19
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

The principle of treating premature ovarian failure is dredging the meridian and activating the collaterals, and the medicinal materials of scorpion vine and honeysuckle are used to dredge the meridian of the patient, so that the blood can flow smoothly, and the essence of acquired water and grain can nourish the congenital kidney essence, thereby improving the treatment effect of premature ovarian failure. There are no research reports

Method used

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  • Traditional Chinese medicine composition used for anti-premature ovarian failure and relevant preparations thereof
  • Traditional Chinese medicine composition used for anti-premature ovarian failure and relevant preparations thereof
  • Traditional Chinese medicine composition used for anti-premature ovarian failure and relevant preparations thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Epimedium 60g, Rehmannia glutinosa 35g, Sunburned Astragalus 35g, Atractylodes macrocephala 20g, Angelica 15g, Tachibana 50g, Lonicera vine 15g, Licorice 6g. Take the above raw materials, wash, remove impurities, pulverize and mix evenly, add 8 times the amount of water to decoct and extract 3 times, combine the extracts, filter, and the filtrate is set aside; add 10 times the amount of 85% ethanol to the filter residue, and extract under reduced pressure for 3 times Once, the extracts were combined, filtered, and the filtrate was set aside; the above-mentioned filtrates were combined and concentrated under reduced pressure to obtain an extract.

[0035] Add 20g of refined honey and 15g of sucrose to the above-mentioned extract, heat to dissolve, mix well, concentrate to a relative density of 1.28, add 0.5g of sodium benzoate while hot, mix well, let cool, and fill to obtain a paste.

Embodiment 2

[0037] Epimedium 40g, Rehmannia glutinosa 40g, Radix Astragali 30g, Atractylodes macrocephala 15g, Angelica 20g, Tengshi vine 50g, Lonicera vine 10g, licorice 7g. Adopt embodiment 1 method to prepare ointment.

Embodiment 3

[0039] Epimedium 80g, Rehmannia glutinosa 30g, Sunburned Astragalus 40g, Atractylodes macrocephala 20g, Angelica 15g, Tachibana 40g, Lonicera vine 20g, Licorice 5g. Adopt embodiment 1 method to prepare ointment.

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Abstract

The invention relates to a traditional Chinese medicine composition used for anti-premature ovarian failure, a preparation method of the traditional Chinese medicine composition and a paste agent. Based on a traditional treatment principle of reinforcing kidney to replenish essence, and invigorating spleen and activating blood, a treatment idea for freeing channels and stimulating circulation of the blood is firstly provided by an inventor, through a lot of pharmacological experiments, two traditional Chinese medicines of Chinese starjasmine stem and Japanese honeysuckle stem are screened to combine with the traditional Chinese medicines (epimeddium, Radix Rehmanniae Preparata, astragalus root, bighead atractylodes rhizome, Chinese angelica and licorice) capable of reinforcing kidney to replenish essence, and invigorating spleen and activating blood to obtain the traditional Chinese medicine composition. The experiment research shows that the traditional Chinese medicine composition is capable of effectively adjusting hormones content in serum (increasing E2 level and reducing FSH level), increasing InhB level, increasing ovary and uterus wet weight, and promoting ovary particle cells proliferation, and can be used for treating premature ovarian failure. In addition, two traditional Chinese medicines of Chinese starjasmine stem and Japanese honeysuckle stem are added to obviously increase the promotion effect of other medicinal materials in the formula to the ovary particle cells proliferation, and especially have synergistic interaction under a specific ratio of 50: 15.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for preventing premature ovarian failure and related preparations thereof. The invention also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Premature ovarian failure (POF), also known as primary ovarian insufficiency, refers to the disorder or cessation of ovulation and hormone secretion function that occurs in women before the age of 40 due to premature ovarian failure, causing menstrual disorders, loss of libido, and sexual function. Gynecological endocrine diseases with a series of symptoms such as decline, infertility, and perimenopausal syndrome. Presenting a state of low estrogen and high gonadotropin, POF seriously endangers women's health, leading to loss of reproductive capacity and genital atrophy in patients. Long-term low estrogen state wil...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/06A61P15/08
CPCA61K9/06A61K36/232A61K36/24A61K36/284A61K36/296A61K36/355A61K36/481A61K36/484A61K36/804A61K47/26A61K47/46A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 吕娜尹艳匡洪影彭艳
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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