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Lethariella cladonioides anti-tumor active parts and preparation and application methods thereof

An anti-tumor activity and active site technology, applied to the anti-tumor active site of red snow tea and its preparation, the preparation of multi-level anti-tumor active site of red snow tea, as an anti-tumor drug and an auxiliary anti-tumor health care product application field, can Solve the problems of limited application and effect of cancer chemotherapy, poor selectivity, and drug resistance of cancer cells

Inactive Publication Date: 2017-12-29
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the cancer chemotherapy drugs currently used clinically have many problems such as large toxic and side effects, uncertain curative effect, poor selectivity, weak targeting, and drug resistance of cancer cells, which make the clinical application and effect of cancer chemotherapy treatment limited. very restrictive

Method used

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  • Lethariella cladonioides anti-tumor active parts and preparation and application methods thereof
  • Lethariella cladonioides anti-tumor active parts and preparation and application methods thereof
  • Lethariella cladonioides anti-tumor active parts and preparation and application methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] The preparation method of anti-tumor active part of red snow tea comprises the following steps:

[0070] Step (1), dry and pulverize lichen hongxue tea, take volume concentration as 60% ethanol as extraction solvent, extract 5 times; the solid-liquid ratio of lichen hong xue tea and the extraction solvent used each time is 1g:5ml; combine The extract is concentrated to a paste to obtain the primary extract;

[0071] In step (2), the primary extract and distilled water are mixed into a suspension in a mass ratio of 1:1, and then adding ethanol with a volume concentration of 100% to obtain a mixed solution; wherein, the amount of ethanol is such that the obtained The volume concentration of ethanol in the mixed solution is greater than 80%; then shake the mixed solution for alcohol precipitation, shake until the mixture is uniform, let it stand for 20 hours, centrifuge at 3500 rpm for 5 minutes, and take the upper liquid; Adopt the ethanol that volume concentration is 80...

Embodiment 2

[0080] The preparation method of anti-tumor active part of red snow tea comprises the following steps:

[0081] Step (1), dry and pulverize lichen hongxue tea, use 70% ethanol as the extraction solvent with a volume concentration, extract 4 times; the solid-liquid ratio of lichen hongxue tea and the extraction solvent used each time is 1g:4ml; combine The extract is concentrated to a paste to obtain the primary extract;

[0082] Step (2), the primary extract and distilled water are mixed into a suspension in a mass ratio of 2:1, and then adding ethanol with a volume concentration of 95% to obtain a mixed solution; wherein, the amount of ethanol is such that the obtained The volume concentration of ethanol in the mixed solution is greater than 80%; then the mixed solution is shaken for alcohol precipitation, after shaking until it is evenly mixed, it is left to stand for 24 hours, centrifuged (2500 rpm, 5 minutes), and the upper layer liquid is taken; the remaining precipitate ...

Embodiment 3

[0091] The preparation method of anti-tumor active part of red snow tea comprises the following steps:

[0092] In step (1), the lichen hongxue tea is dried and pulverized, and the volume concentration is 65% ethanol as the extraction solvent, and extracted 4 times; the solid-liquid ratio of the lichen hongxue tea and the extraction solvent used each time is 1g:4.5ml; The combined extracts are concentrated to a paste to obtain primary extracts;

[0093] Step (2), the primary extract and distilled water are mixed into a suspension at a mass ratio of 1.5:1, and then adding ethanol with a volume concentration of 98% to obtain a mixed solution; wherein, the amount of ethanol is such that the obtained The volume concentration of ethanol in the mixed solution is greater than 80%; then the mixed solution is shaken for alcohol precipitation, after shaking until it is evenly mixed, it is left to stand for 22 hours, centrifuged (3000 rpm, 5 minutes), and the upper layer liquid is taken;...

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Abstract

The invention relates to a lethariella cladonioides anti-tumor active parts and preparation and application methods thereof and belongs to the technical field of plant drugs. The lethariella cladonioides anti-tumor active parts are mixtures with significant anti-tumor effects, which are prepared by taking lethariella cladonioides as raw materials and combining anti-tumor activity detection. The lethariella cladonioides anti-tumor active parts achieve significant cell-targeted and selective anti-tumor effects as well as synergistic or additive anti-tumor effects with clinical anti-tumor chemotherapeutic drugs, and can significantly promote apoptosis of tumor cells, affects period distribution of the tumor cells and inhibit proliferation of tumor cells. Different lethariella cladonioides anti-tumor active parts have large differences in anti-tumor effects. The l lethariella cladonioides anti-tumor active parts can be prepared into various reagents and serve as anti-tumor drugs, compound anti-tumor healthcare products and auxiliary anti-tumor healthcare products, thereby having a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of herbal medicines, and relates to a red snow tea anti-tumor active part and its preparation method and application, in particular to a red snow tea (also known as deer heart snow tea, golden thread tea, English name: Lethariella cladonioides) The preparation of multi-level anti-tumor active sites (this application is referred to as AMH, which is the abbreviation of Antimutagen-He), the discovery of its anti-tumor effect, and its application as anti-tumor drugs and auxiliary anti-tumor health products. Background technique [0002] Malignant tumor is a major disease that seriously threatens human health and life safety. It has become the main cause of death of human beings and seriously threatens human health and life safety. According to data released by the International Cancer Institute of the World Health Organization in Globocan, there were 12.661 million new cancer cases and 7.564 million deaths world...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/09A61P35/00
CPCA61K36/09A61K2236/333A61K2236/39A61K2236/53A61K2236/55
Inventor 贺小琼
Owner KUNMING MEDICAL UNIVERSITY
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