Haemostatic and wound healing medicine

A technology of coagulant and medicament, applied in drug combination, blood diseases, aerosol delivery, etc., can solve the problems of long hemostasis time, short action time, embryo toxicity and so on

Inactive Publication Date: 2018-01-02
顶盖有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A significant disadvantage of dioxins is their mutagenic activity, embryotoxicity, and potential to damage the adrenal cortex
A disadvantage of the known composition is that 2-allyloxyethanol and chlorhexidine can cause allergic reactions including anaphylactic shock
The results showed that the drug had a short duration of action and prolonged hemostasis

Method used

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  • Haemostatic and wound healing medicine
  • Haemostatic and wound healing medicine
  • Haemostatic and wound healing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The mixture of chitosan salt and chitosan block polylactide was supplemented with aspartic acid, which formed a stable gel. The gel based on chitosan and chitosan block-polylactide (5.0 wt %) was supplemented with organocalcium compounds, a natural thrombogenic component in the form of calcium glycerophosphate in an amount of 0.2 wt %, and the remainder was made up with water for 100 weight%.

[0031] Examples 2-7 were carried out in a similar manner to Example 1 .

[0032] Data are summarized in tables.

[0033] Table 1

[0034]

[0035]

[0036]

[0037] An increase in the amount of chitosan over 30 wt% will result in significant structuring of the system, and a decrease of less than 0.2 wt% will result in difficulty in forming a three-dimensional structure

[0038] An increase in the amount of natural thrombogenic components in the form of Ca organic compounds by more than 10% does not lead to further improvement in the performance of the composition, does ...

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Abstract

The proposed invention is related to medicine, in particular to haemostatic and wound healing medicines, and can be used to stop bleeding of various levels of severity, inter alia, venous bleeding, aswell as for healing wounds and cuts sustained as a result of mechanical action on the epidermal and muscle tissue layers. To this end a haemostatic medicine comprising an active gelling component based on chitosan and / or a derivative thereof is used, characterized in that the medicine comprises chitosan, salts thereof and / or derivatives thereof in the form of a gel having a three-dimensional cross-linked structure as a polymeric matrix with natural thrombosis components in the form of organic calcium compounds arranged thereon, an organic acid and water, the components being present in a certain ratio. The technical result of the use of the invention is the quicker stoppage of bleeding of various levels of severity and the creation of an antibacterial effect.

Description

technical field [0001] The present invention relates to a medicament, a hemostatic and wound healing agent, that can be used to stop bleeding of various severity, including venous bleeding, and can be used to heal mechanically induced wounds and incisions in the epidermal and muscular layers of tissue. Background technique [0002] Currently, various hemostatic and wound healing agents are being actively developed in medicine, veterinary medicine, pharmacy and the like. [0003] At present, tools such as bandages, hemostatic sponges, and hemostatic powders are used in first aid. The main disadvantage of all available tools is that they need to be removed from the wound after application, thereby re-inflicting mechanical damage. This is why it is a related challenge to create an atraumatic hemostatic agent that mimics natural hemostasis, is biocompatible with living human tissue and possesses both wound healing and bactericidal properties. [0004] There is a therapeutic ag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/36A61K9/06A61K31/19A61K31/195A61K31/455A61K33/38A61L15/28A61P17/02
CPCA61K9/06A61K31/19A61K31/195A61K31/455A61K33/38A61K31/191A61K31/197A61K31/198A61K31/661A61L26/0052A61L2300/624A61L2400/10A61L2300/21A61L26/0004A61L2300/104A61P17/02A61L26/0066A61L26/008A61L26/0023A61L2400/04A61P7/04C08L5/08C08L33/10C08L67/04C08L39/06A61L15/28A61K47/32A61K47/36
Inventor A·S·科耶金A·E·莫查洛娃L·A·斯米尔诺娃K·V·阿普勒耶基纳E·N·格里高力娃
Owner 顶盖有限责任公司
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