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Plant extract for treating cancer metastasis and preparation method thereof

A cancer metastasis and extract technology, applied in the field of medicine, can solve the problems of poor effect and limited methods of cancer metastasis, and achieve the effects of high extraction efficiency, treatment of lung cancer brain metastasis, and safe and simple operation.

Pending Publication Date: 2018-01-09
湖南晓林生物科技发展有限公司
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  • Description
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AI Technical Summary

Problems solved by technology

Existing treatments for cancer metastasis are extremely limited and ineffective

Method used

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  • Plant extract for treating cancer metastasis and preparation method thereof
  • Plant extract for treating cancer metastasis and preparation method thereof
  • Plant extract for treating cancer metastasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] Preparation of Hedyotis diffusa extract:

[0052] 1) Dried Hedyotis diffusa at 55-65°C and crushed to 80-120 mesh, adding 5-15 times of water, stirring and extracting at 45-55°C for 4 hours;

[0053] 2) Remove insoluble matter, use a 0.45 μm filter membrane for primary filtration, and then use a 0.22 μm filter membrane for secondary filtration, collect the obtained filtrate and freeze-dry to obtain the Hedyotis diffusa extract.

[0054] The above-mentioned Hedyotis diffusa extract was taken for detection, and the detection results were as follows: Figure 1~3 shown. in, figure 1 It is the absorbance curve of the aqueous solution of Hedyotis diffusa extract (300mg / mL) at a wavelength of 200nm to 600nm, showing that it has a peak at 282.5nm, and its absorbance reaches 0.981; figure 2 is the liquid chromatogram of Hedyotis diffusa extract; image 3 is another liquid chromatogram of Hedyotis diffusa extract and the mass spectrum of its main peak.

[0055] After testin...

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Abstract

The invention discloses plant extract for treating cancer metastasis and a preparation method thereof. After many years of researches, the inventor finds out and confirms that herba hedyotidis diffusae extract can be used for locking and selectively treating the cancer metastasis for the first time, and the effective rate of the herba hedyotidis diffusae extract on the cancer metastasis reaches 99.8 percent to 99.9 percent, so that the herba hedyotidis diffusae extract hopefully becomes a medicine which has an extremely great attraction force and is used for treating the cancer metastasis, especially lung cancer with brain metastasis and lymphatic metastasis of cancer. A possible acting mechanism is that the effect of resisting the cancer metastasis is realized through inhibiting cell proliferation, inducing cell apoptosis and inhibiting angiogenesis. The plant extract disclosed by the invention has a relatively strong targeting ability on the treatment of the cancer metastasis, does not have the drug resistance and has no crossed drug resistance with a traditional chemotherapeutic drug. The herba hedyotidis diffusae extract is safe and has no toxin, and hopefully becomes a novel plant medicine which is used for treating the cancer metastasis, especially the lung cancer with the brain metastasis and the lymphatic metastasis of the cancer.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a plant extract and its preparation method and application, in particular to an extract of Hedyotis diffusa and its preparation method and application. Background technique [0002] As we all know, malignant tumor is a kind of frequently-occurring and common disease that seriously threatens human health. Together with viral diseases and senile diseases, it is called the three major challenges of modern medicine. Its pathogenesis has not been fully elucidated, and the treatment effect is not satisfactory. According to incomplete statistics, the global average annual R&D and treatment expenses for tumors are tens of billions, which brings huge losses to the country, society and individuals. [0003] Metastatic cancer refers to the invasion of tumor cells from the primary site into lymphatic vessels, blood vessels or other pathways to it to continue to grow, forming a tumor of the same type ...

Claims

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Application Information

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IPC IPC(8): A61K36/748A61P35/04
Inventor 谢丹
Owner 湖南晓林生物科技发展有限公司
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