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Application of total flavone extract of Tagetes patula in treatment of climacteric syndrome

A technology of total flavonoids and peacock grass, which is applied in the direction of drug combinations, medical preparations containing active ingredients, plant raw materials, etc., and can solve problems such as adverse reactions and unwanted reactions

Inactive Publication Date: 2018-01-16
蔡德成 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hormone replacement therapy is commonly used in modern clinics to treat menopausal syndrome in women. It can improve symptoms to a certain extent, but it is also easy to cause a variety of adverse reactions, including uterine cancer, breast cancer, etc., which has become a serious clinical adverse reaction.

Method used

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  • Application of total flavone extract of Tagetes patula in treatment of climacteric syndrome
  • Application of total flavone extract of Tagetes patula in treatment of climacteric syndrome
  • Application of total flavone extract of Tagetes patula in treatment of climacteric syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 prepares the total flavonoids of Malachite

[0015] Preparation of total flavonoids of malachite grass by solvent extraction and resin adsorption:

[0016] 1 kg of malachite grass powder with 10 meshes and 80% ethanol by volume is soaked and extracted twice, the amount of solvent used each time is 10 times the mass of the medicinal material, and soaked at 40°C for 12 hours each time. Combine the extracts, recover the ethanol solution, concentrate to about 1 times the mass of the medicinal material (about 1 liter), and extract 3 times with 500 ml of petroleum ether each time to obtain a degreased solution. The degreasing solution is eluted with water (2500 milliliters) and 60% ethanol aqueous solution (2000 milliliters) successively through the pretreated HPD100 macroporous adsorption resin column (about 500 milliliters), and the 60% ethanol eluent is recovered under reduced pressure Ethanol, dried under reduced pressure to obtain 105g of total flavonoids e...

experiment example 1

[0017] Experimental example 1: Therapeutic effect of total flavonoids extract of Malacock grass on castrated rat model of climacteric syndrome

[0018] 1.1 Experimental materials

[0019] 1.1.1 Animals

[0020] Animals: SPF grade, SD rats, female, non-pregnant at childbearing age, weighing 200-220 g, purchased from Liaoning Changsheng Biotechnology Co., Ltd., [SCXK (Liao) 2010-0001].

[0021] 1.1.2 Drugs

[0022] Preparation of medicine: take an appropriate amount of the above-mentioned total flavonoids extract of Malachite grass, add 0.5% sodium carboxymethyl cellulose aqueous solution to prepare solutions with a concentration of about 10 mg / ml, 20 mg / ml and 40 mg / ml, and set aside.

[0023] Penicillin powder for injection, Harbin Pharmaceutical Group General Pharmaceutical Factory, batch number: CA1406017-2;

[0024] Kunbao Pills, Beijing Tongrentang Co., Ltd. Tongrentang Pharmaceutical Factory, batch number 2035165. Specifications: 10g per 100 pills. The clinical human...

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Abstract

The invention relates to application of total flavone extract of Tagetes patula in treatment of woman climacteric syndrome, the whole grass of the Tagetes patula is crushed, refluxed extracted with ethanol, degreased by petroleum ether, and purified by macroporous resin to obtain the total flavone extract of the Tagetes patula, the total flavone extract of the Tagetes patula is determined by a colorimetric method, and the weight of total flavones is 30% or more. Pharmacological tests show that the total flavone extract of the Tagetes patula has strong treatment effect on the climacteric syndrome, and can be used as a raw material drug alone or in combination with other drugs in preparations of anti climacteric syndrome drugs. The total flavone extract prepared from the Tagetes patula by the method has high purity, and the preparation method is simple and practical, and is suitable for industrial production. The total flavone extract of the Tagetes patula can be used for preparing drugsfor treating the climacteric syndrome. Inventors: Cai Decheng, Dou Deqiang.

Description

technical field [0001] The invention relates to a herbal drug extraction method and application thereof, in particular to a drug extract with malachite total flavonoids as an active ingredient and its application in treating menopausal syndrome. Background technique [0002] Peacock grass (Tagetespatula L.), also known as small marigold, red yellow grass, passionflower, stinky chrysanthemum, satin flower (Yunnan), is a plant of the genus Marigold in the Asteraceae family. It is an annual herb with a flowering period from July to September. Originally produced in Mexico, it has been naturalized in central and northwestern Yunnan, central and southwestern Sichuan, and western Guizhou. It is now cultivated in various places in my country. It is a common ornamental flower. Peacock grass has medicinal and health care functions, and is used as medicine in the Lisu and Yi nationalities. Its taste is bitter and flat, clearing away heat and promoting dampness, relieving cough. For ...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P15/12
Inventor 蔡德成窦德强
Owner 蔡德成
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