Peritoneal metastasis prediction model of gastric cancer based on 22 genes and application thereof

A technology of metastasis prediction and gene, applied in the direction of microbial measurement/testing, biochemical equipment and methods, etc., can solve the problems of gene model prediction or diagnosis of gastric cancer, etc., to achieve specific and effective prediction, good accuracy, and improve survival rate Effect
CN107586852AActive Publication Date: 2018-01-16FUJIAN MEDICAL UNIV UNION HOSPITAL +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUJIAN MEDICAL UNIV UNION HOSPITAL
Publication Date
2018-01-16

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Abstract

The invention belongs to the field of genetic testing and provides a peritoneal metastasis prediction model of a gastric cancer based on 22 genes and application thereof, including PCLO, UGGT1, ZNF714, KIAA0825, COL23A1, MED1, NPAS2, TTC14, RPS27A, ASPH, ARHGEF12, SIK1, PAPPA, HHIPL1, MYO9B, ITPKB, ZNF862, MKNK1, MUC6, TRRAP, DUOX1 and KRTAP5-2; a risk of peritoneal metastasis is predicted effectively and specifically, according to SVM of a selected classifier and a positive judgment threshold value of 0.5. The application of the gene model of the invention is helpful for predicting the metastasis of patients with gastric cancer and has important value and significance for taking timely and effective clinical measures, making an individualized diagnosis and treatment plan and finally improving a survival rate of the patients with the gastric cancer.
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Description

technical field

[0001] The invention belongs to the field of gene detection, and in particular relates to a gene model for predicting peritoneal metastasis of gastric cancer and its application. Background technique

[0002] According to the latest statistics, gastric cancer is a malignant tumor with the fourth highest incidence rate and the second highest mortality rate in the world, and the highest mortality rate of gastric cancer in my country is the third highest among malignant tumors. Early gastric cancer has no obvious symptoms, and most patients are in the middle and late stages when they see a doctor, and there is no effective treatment. Peritoneal metastasis is the main way of gastric cancer metastasis. Peritoneal metastasis is found in 10-25% of gastric cancer patients before or during operation, and 30-60% of patients after radical operation still have peritoneal metastasis. Therefore, peritoneal metastasis of gastric cancer is the main cause of death and the bo...

Claims

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