Production process for synthesizing macrolide antibiotics special for poultry and livestock through fermentation of acetylisovaleryltylosin tartrate

Abstract

The invention provides a production process for synthesizing macrolide antibiotics special for poultry and livestock through fermentation of acetylisovaleryltylosin tartrate. The production process for synthesizing macrolide antibiotics special for poultry and livestock through fermentation of acetylisovaleryltylosin tartrate comprises a fermentation step, and specifically comprises the followingsteps: A, carrying out primary metabolism thallus culture, namely, carrying out culture so that hyphae grow; and B, carrying out secondary metabolism rhzomorph culture, namely, supplementing the substrate, namely, tylosin solution, adjusting the temperature and carrying out fermentation at 27-29 DEG C, so that the macrolide antibiotics special for poultry and livestock are generated. For the production process for synthesizing macrolide antibiotics special for poultry and livestock through fermentation of acetylisovaleryltylosin tartrate, the content of the component for fermenting the macrolide antibiotics special for poultry and livestock is relatively high, the content of the final component can achieve 80% or above, 3-5 percentage points are improved compared with the prior art, and thus a foundation is laid for the promotion of the quality of the product.

Description

technical field [0001] The invention belongs to the field of microbial fermentation engineering, and in particular relates to a production process for synthesizing macrolide antibiotics special for poultry and livestock by fermenting tyvanectin. Background technique [0002] Tyvanectin fermentation is a kind of macrolide antibiotics specially used for livestock and poultry which is semi-synthesized on the basis of tylosin by microbial fermentation. During the fermentation process, the content of macrolide antibiotic components for poultry and livestock in tyvalactin largely determines the content of antibiotic components for macrolide and livestock in the finished product, so the macrolide antibiotic components in the fermentation process should be increased. Antibiotic components for poultry and livestock are of great significance to the improvement of product quality. Contents of the invention [0003] In order to solve the technical problem that the obtained component ...

AI Technical Summary

Problems solved by technology

[0003] In order to solve the technical problem that the obtained component content is low in the synthesis of macrolide antibiotics for poultry and livestock under the existing tivalamectin fermentation conditions, the present invention provides a synthetic macrolide antibiotic component for poultry and livestock Production process of fermenting and synthesizing macrolide antibiotics for poultry and livestock with high content of tivalamectin

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