Indoloquinazine-6-formyl-3-glucosamine, its preparation, activity and application

A technology of glucosamine and quinozine, which is applied in the field of indoloquinazine-6-formyl-3-glucosamine, its preparation, activity and application, and can solve the problems of worsening prognosis of tumor patients and poor prognosis of tumor patients
CN107686499BActive Publication Date: 2020-01-17CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Publication Date
2020-01-17

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Abstract

The invention provides (6S)-3-acetyl base-4-oxo-4,6,7,12-tetraindole-[2,3-alpha]quinolizine-6-formyl-(3-glucosamine), provides a preparation method thereof, discloses the anti-tumor activity thereof in a mice S180 transplanted sarcoma model, discloses the anti-tumor metastasis activity thereof in a mice Lewis lung cancer metastasis model, discloses an anti-inflammation role thereof in a mice ear swelling model, and further discloses an anti-thrombus role thereof in a rat common carotid artery-external jugular vein circulation bypath thread method anti-thrombus model. The invention discloses application of (6S)-3-acetyl base-4-oxo-4,6,7,12-tetraindole-[2,3-alpha]quinolizine-6-formyl-(3-glucosamine) in preparation of anti-tumor drugs, anti-lung cancer metastasis drugs, anti-inflammation drugs and anti-thrombus drugs.
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Description

technical field

[0001] The present invention relates to (6S)-3-acetyl-4-oxo-4,6,7,12-tetrahydroindolo[2,3-α]quinazine-6-formyl-(3-glucosamine ), referred to as ATIQC-TMTP, related to its preparation method, related to its anti-tumor activity on the mouse S180 transplanted sarcoma model, related to its anti-tumor metastasis activity on the mouse Lewis lung cancer metastasis model, and related to its anti-tumor activity on the mouse Lewis lung cancer metastasis model. The anti-inflammatory effect on the ear swelling model further relates to its antithrombotic effect on the common carotid artery-external jugular vein circulation bypass silk thread method antithrombotic effect in rats. The present invention thus relates to (6S)-3-acetyl-4-oxo-4,6,7,12-tetrahydroindolo[2,3-α]quinazine-6-formyl-(3-amino Glucose) in the preparation of anti-tumor drugs, anti-tumor lung cancer metastasis drugs, anti-inflammatory drugs and antithrombotic drugs. The invention belongs to the field of bi...

Claims

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