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Applications of polygala tenuifolia willd aerial part extract in preparation of anti-stress drugs or health care products

An extract and anti-stress technology, which can be used in drug combinations, medical preparations containing active ingredients, anti-toxins, etc., can solve problems such as differences in efficacy

Inactive Publication Date: 2018-02-16
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Polygala seedlings and Polygala root originate from the same plant, there are certain differences in efficacy. The efficacy of Polygala seedlings is mostly tonic

Method used

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  • Applications of polygala tenuifolia willd aerial part extract in preparation of anti-stress drugs or health care products
  • Applications of polygala tenuifolia willd aerial part extract in preparation of anti-stress drugs or health care products
  • Applications of polygala tenuifolia willd aerial part extract in preparation of anti-stress drugs or health care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Extraction method has ultrasonic extraction method, heating reflux method, dipping method etc., and contriver has selected simple and fast ultrasonic extraction method, after drying and pulverizing Polygala seedlings, extract with 60% ethanol of 10 times of volume, investigated extraction time (15 minutes , 25 minutes, 35 minutes) and the number of extractions (2 times and 3 times) on the extraction rate. The results showed that when the number of extractions was 1, the extraction rates of the extraction time (15 minutes, 25 minutes, 35 minutes) were 16.2%, 18.5%, 20.4% respectively; when the number of extractions was 2, the extraction rates of the extraction time (15 minutes, 25 minutes, 35 minutes) extraction rate: 22.1%, 23.9%, 25.2%. The final optimal condition is: extract 3 times, and the extraction time is 35 minutes. A preferred example is as follows: After drying and crushing 10 kg of Polygala seedlings, ultrasonically extract with 10 times the volume of 60% et...

Embodiment 2

[0016] In order to verify the anti-stress effect of the polygala seedling extract, the inventor has carried out pharmacodynamic tests on anti-fatigue, hypoxia resistance, and cold resistance. The test conditions are as follows:

[0017] 1. Experimental drug

[0018] Polygala shoots extract was prepared according to Example 1.

[0019] 2. Main experimental instruments and reagents

[0020] Plastic container (40cm×30cm×30cm), load 5g, 500ml jar with lid, 20g soda lime (manufacturer: Beijing Delly Sodium Lime Factory), low-temperature refrigerator, timer.

[0021] 3. Experimental animals

[0022] Male Kunming mice, weighing 20-25 g, were provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine.

[0023] 4. Experimental grouping and drug administration method

[0024] The mice were randomly divided into two groups, 10 in each group. The Polygala seedling extract treatment group was administered with Polygala seedling extract (equivalent to 1.2...

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Abstract

The invention discloses applications of a polygala tenuifolia willd aerial part extract in preparation of anti-stress drugs or health care products, wherein the polygala tenuifolia willd aerial part extract preparation method comprises: drying a polygala tenuifolia willd aerial part, crushing, carrying out ultrasonic extraction for 15-35 min 1-2 times with 7-10 times the volume of 30-70% ethanol,recovering the solvent, carrying out pressure reducing concentration, and carrying out vacuum drying to obtain the polygala tenuifolia willd aerial part.

Description

technical field [0001] The invention relates to the application of polygala seedling extract in the preparation of anti-stress medicine or health care product, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Polygala seedlings, also known as small grass, fine grass, and green grass, are Polygala plants of the Polygalaceae family. Polygala tenuifolia The above-ground part of Willd., some areas also include Polygala ovale P. sibirica The aerial part of L. can only be used in folks, or circulated in Chinese herbal medicine markets in Zhejiang, Hebei, Jiangsu and Shanghai. Polygala is Polygala polygala Polygala tenuifolia Willd. or Polygala ovale P. sibirica The dried root of L. is included in the previous editions of "Chinese Pharmacopoeia". It is the legal genuine Polygala medicinal material in the national Chinese medicinal material market, and is also a legal raw material for processing Polygala decoction pieces a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A61P39/00
CPCA61K36/69A61K2236/333A61K2236/39A61K2236/51
Inventor 房敏峰张典张丹婷李忠虎郑军明李荣
Owner NORTHWEST UNIV(CN)
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