Application of osteocalcin to regulation of exosomes of endothelial progenitor cells

A technology of endothelial progenitor cells and osteocalcin, which is applied in the field of biomedicine to achieve the effect of increasing the diameter and promoting proliferation
CN107899002AActive Publication Date: 2018-04-13XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
Publication Date
2018-04-13

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Abstract

The invention relates to application of osteocalcin to the regulation of exosomes of endothelial progenitor cells. The regulation relates to number and diameter distribution of the exosomes. The regulated exosomes can obviously promote multiplication and migration of endothelial cells, and ensure that the endothelial cells rapidly produce vessels. The discovery of a regulation mechanism provides novel thought for the treatment of ischemic diseases.
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Description

Technical field

[0001] The invention relates to the field of biomedicine, in particular to the application of osteocalcin (OCN) in regulating endothelial progenitor cell exosomes. Background technique

[0002] Osteocalcin (OCN), also known as bone Gla protein, or bone γ-Carboxyglutamic Acid Containing Protein (BGLAP or BGP), or bone-dependent vitamin K protein (BoneVitamin K Dependent Protein), It is a structural protein specifically synthesized and secreted by osteoblasts, odontoblasts and hypertrophic chondrocytes. It is one of the components that constitute the bone matrix. Glutamate residues in osteocalcin molecules are converted into gamma-carboxyglutamate (Gla) residues through vitamin K-dependent post-translational modification. The γ-carboxylated osteocalcin molecule contains 3 Gla residues. Active vitamin D promotes the biosynthesis of γ-carboxylated osteocalcin in osteoblasts. γ-carboxylated osteocalcin is called active osteocalcin, which can bind to calcium through ...

Claims

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