Application of imca in the preparation of antithyroid cancer drugs

Abstract

The invention relates to application of IMCA in preparation of anti-thyroid cancer drugs, and the chemical structure of the IMCA is as shown in the description. MTT results reveal that proliferation of thyroid tumor cells can be significantly inhibited by the IMCA, and localization of NR4A1 from nucleus to cytoplasm can be induced. Annexin V and PI double staining apoptosis detection results reveal that apoptosis can be induced by the IMCA. According to the application, development is conducted by taking the small molecular compound IMCA as the novel anti-thyroid tumor drugs or helper constituents of the novel anti-thyroid tumor drugs, tumor inhibiting effects are significant, and new approaches and means for treating and healing thyroid tumors are provided.

Description

technical field [0001] The invention belongs to the technical field of chemical industry and medicine, and in particular relates to the application of IMCA in the preparation of antithyroid cancer drugs. Background technique [0002] Thyroid cancer is the most common malignancy of the head and neck, and its incidence has increased approximately 2.4-fold over the past 30 years. Although it only accounts for 1% of systemic malignant tumors, its incidence has risen rapidly in recent years, and it has become one of the fastest-growing tumors in human malignant tumors. The incidence of thyroid cancer continues to rise, and its treatment and prevention have aroused widespread concern in society. So far, for the treatment of thyroid cancer, although there are many methods such as traditional Chinese medicine adjuvant therapy, surgery, radiotherapy and chemotherapy are still the main treatments. Surgical treatment has a relatively large degree of damage to the patient's body, and ...

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Problems solved by technology

IMCA is a derivative of Benzopyrano[2,3-d]pyrimidine,

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