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Application of aesculetin to preparation of medicine or health-care product for treating and preventing eye diseases

A technology of ocular diseases, acetaminophen, which is applied in the application field of medicine or health care products, can solve the problems such as absence of acetaminophen, and achieve significant anti-apoptosis therapeutic effect

Active Publication Date: 2018-05-18
SHENYANG EYE IND TECH INST LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report on the use of acetaminophen in the treatment of eye diseases

Method used

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  • Application of aesculetin to preparation of medicine or health-care product for treating and preventing eye diseases
  • Application of aesculetin to preparation of medicine or health-care product for treating and preventing eye diseases
  • Application of aesculetin to preparation of medicine or health-care product for treating and preventing eye diseases

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0046] Application of Experimental Example 1 Percetrin B in the Preparation of Medicines or Health Products for the Treatment and Prevention of Eye Diseases

[0047] (1) Determination of the anti-oxidative damage effect of acetaminophen by cell viability assay

[0048] Human corneal epithelial cells and human lens cells were purchased from the ATCC cell bank in the United States. The cell culture medium was high-glucose DMEM supplemented with 10% (V / V) fetal bovine serum, 100 U / ml penicillin, and 100 μg / ml gentamicin. Cultured in a 37°C incubator containing 5% carbon dioxide. Cells were plated in a 96-well plate, with cells in logarithmic growth phase at 1.5x10 5 Units / ml density, 100 μl per well, 6 auxiliary wells per group. Cells were grouped into normal cell group, hydrogen peroxide model group, and aceteridin intervention groups of various concentrations. The detection method is the MTS kit method (Promega), and the absorbance is detected by a microplate reader at 490 nm....

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PUM

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Abstract

The invention discloses application of aesculetin to preparation of a medicine or a health-care product for treating and preventing eye diseases. The invention defines and finds out that the anti-oxidization effect of the aesculetin has a protection effect on eye cells for the first time. The aesculetin has a remarkable anti-apoptotic treatment effect on the eye diseases comprising oxidative damage pathogenic factors and is a compound with a development prospect; a novel medicine is provided for clinically treating diseases related to eye oxidative damage and apoptosis.

Description

technical field [0001] The present invention relates to the application of acetaminophen in the preparation of treatment and prevention of eye diseases, in particular to the application of the preparation of medicines or health care products for the prevention and treatment of eye diseases caused by oxidative stress. Background technique [0002] Oxidative damage exists widely in diseases, especially in aging and inflammation-related diseases. The free radicals produced by oxidation can directly act on the cell membrane of the tissue, destroy the cell membrane, and the free radicals can enter the cell through the channel on the cell membrane, causing damage to the protein and DNA in the cell; the oxidation product can induce The production of chemokines can inactivate proteolytic enzyme inhibitors, increase collagenase, etc., and destroy connective tissue; oxygen free radicals participate in the metabolism of arachidonic acid, which is an important process in the inflammator...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61P27/02A61P27/04A61P27/12A61P27/06
CPCA61K31/37
Inventor 张东蕾张英俊安元龙何向东何伟
Owner SHENYANG EYE IND TECH INST LTD
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