Application of IMCA in preparation of anti-gastric-cancer drug

Abstract

The invention relates to an application of IMCA in preparation of anti-gastric-cancer drug. The chemical structure of IMCA is shown as below: the structure is as shown in specification. The MMT resultshows that IMCA can significantly inhibit tumor cell proliferation and induce NR4A1 location from cell nucleus to cytoplasm. The double-staining apoptosis detection result of Annexin V and PI shows that the IMCA can induce cell apoptosis. The small molecule compound is developed as a new anti-gastric-cancer drug or its auxiliary element; the cancer inhibiting effect is significant, the application provides a new way and a new manner for treating and curing gastric tumor.

Description

technical field [0001] The invention belongs to the technical field of chemical industry and medicine, and in particular relates to the application of IMCA in the preparation of anti-gastric cancer drugs. Background technique [0002] Gastric cancer is one of the most common malignant tumors in the Chinese population, with an annual incidence of new cases and deaths exceeding 70%. There are significant regional differences in the incidence of gastric cancer worldwide, with a higher incidence in Southeast Asia. The incidence of gastric cancer continues to increase, and its treatment and prevention have aroused widespread concern in society. So far, for the treatment of gastric cancer, although there are various methods such as traditional Chinese medicine adjuvant therapy, surgery and chemotherapy are still the main treatments. Surgical treatment has a relatively large degree of damage to the patient's body, and the stage of tumor progression also determines the feasibility...

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Problems solved by technology

IMCA is a derivative of Benzopyrano[2,3-d]pyrimidine,

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