Application of valeric acid in preparation of medicine for preventing and/or curing tumor radiotherapy side reactions

A technology of tumor radiotherapy and side effects, applied in the field of medicine, can solve the problems of restricting wide application, side effects, short duration of amifostine drug effect, etc.

Active Publication Date: 2018-06-08
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary, due to the short duration of efficacy of amifostine after administration and the side effects of its own administration, its wide application in clinical practice is limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of valeric acid in preparation of medicine for preventing and/or curing tumor radiotherapy side reactions
  • Application of valeric acid in preparation of medicine for preventing and/or curing tumor radiotherapy side reactions
  • Application of valeric acid in preparation of medicine for preventing and/or curing tumor radiotherapy side reactions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Survival rate and weight detection of mice after abdominal local irradiation with γ-rays.

[0053] 1. Experimental animals:

[0054] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into two groups: a control group and a valeric acid administration group, 30 mice in each group.

[0055] 2. Model establishment:

[0056] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 15Gy, and the dose rate is 1Gy / min.

[0057] 3. Administration method:

[0058] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous solution) concentrati...

Embodiment 2

[0065] Example 2: Detection of intestinal goblet cells in mice after abdominal local irradiation with γ-rays.

[0066] 1. Experimental animals:

[0067] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into three groups: blank group, simple irradiation group and valeric acid administration group, 30 in each group.

[0068] 2. Model establishment:

[0069] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 12Gy, and the dose rate is 1Gy / min.

[0070] 3. Administration method:

[0071] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous so...

Embodiment 3

[0079] Example 3: Detection of colon length in mice after localized abdominal irradiation with γ-rays.

[0080] 1. Experimental animals:

[0081] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into three groups: blank group, simple irradiation group and valeric acid administration group, 30 in each group.

[0082] 2. Model establishment:

[0083] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 12Gy, and the dose rate is 1Gy / min.

[0084] 3. Administration method:

[0085] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous solution)...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of medical technology, and relates to application of valeric acid in the preparation of medicine for preventing and/or curing tumor radiotherapy side reactions. Researches find that valeric acid can obviously improve intestinal injury, caused by partial irradiation on abdomen of gamma ray, of a mouse, so that the survival rate of the laboratory mouse is obviouslyincreased, the weight is expected to be increased, the level of intestinal inflammation is obviously reduced; and no paradoxical reaction appears on the laboratory mouse, so that valeric acid can beeffectively used for preventing and/or curing tumor radiotherapy side reactions, and the toxic and/or side effects are relatively low.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the use of valeric acid in preparing medicines for preventing and / or treating side effects of tumor radiotherapy, in particular to the use of valeric acid in preparing medicines for preventing and / or treating side effects of radiotherapy for pelvic and abdominal tumors use in . Background technique [0002] Epidemiological studies have shown that cancer has become one of the diseases with the highest morbidity and mortality in the world. The 2017 cancer report shows that about 10,000 people are diagnosed with cancer every day, and an average of 7 people are diagnosed every minute. There are about 14.09 million new cases in the world, and China accounts for 1 / 4 of the world's new cases. [0003] Belly and abdominal tumors include digestive system tumors (such as gastric cancer, liver cancer, pancreatic cancer, colon cancer, rectal cancer, etc.), urinary system tumors (such as kid...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P1/12A61P1/08A61P1/00A61P3/00
CPCA61K31/19
Inventor 崔明樊赛军李源肖惠文张书琴
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap