Purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury

A technology of dihydroxyphenyl and activator, applied in the field of medicine

Active Publication Date: 2018-06-08
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Protocatechualdehyde, danshensu, salvianolic acid B and salvianolic acid A belong to salvianoli

Method used

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  • Purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury
  • Purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury
  • Purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Experimental materials

[0051] 1.1 Instruments and equipment

[0052] Ultra-clean bench (Thermo Scientific 1300A2, USA); multifunctional microplate reader FLUOstar Omega (BMG LABTECH, Germany); electronic scale (Tianjin Tianma Hengji Instrument Co., Ltd.); Sartorius analytical balance (Beijing Doris Balance Co., Ltd.); Eppendorf Desktop multifunctional high-speed centrifuge (type 5430, Germany).

[0053] 1.2 Reagents

[0054] Standard products: protocatechualdehyde, danshensu, salvianolic acid B, and salvianolic acid A were purchased from Chengdu Master Biotechnology Co., Ltd.

[0055] Reagents: DMEM high-glucose medium, fetal bovine serum, 100× penicillin and streptomycin (Thermo Fisher, USA); PBS (Beijing Boaosen Biotechnology Co., Ltd.); CCK8 (Shanghai Dongren Chemical Technology Co., Ltd.); DMSO (sigma, the United States); ALDA-1 (MedChem Express); mitochondrial acetaldehyde dehydrogenase 2 activity detection kit (abcam, UK); rat 4-hydroxynonenoic acid ELISA ...

Embodiment 2

[0168] 1. Tablet

[0169] Protocatechualdehyde, danshensu, salvianolic acid B or salvianolic acid A 70g, starch 180g, magnesium stearate 3g.

[0170] Preparation process: Danshensu, salvianolic acid B or salvianolic acid A, starch and magnesium stearate are mixed uniformly, granulated, dried, and compressed into tablets.

[0171] 2. Capsules

[0172] Meliasenin B, C or D 70g, starch 180g, magnesium stearate 3g.

[0173] Preparation process: Danshensu, salvianolic acid B or salvianolic acid A, starch and magnesium stearate are mixed and granulated, dried and packed into capsules.

[0174] In summary, the present invention provides 3,4-dihydroxyphenyl substituted phenolic compounds including but not limited to protocatechualdehyde, danshensu, salvianolic acid B, and salvianolic acid A for the preparation of ALDH2 activators Uses, and further provide the use of the 3,4-dihydroxyphenyl substituted phenolic compound for the preparation of drugs for the prevention and treatment o...

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PUM

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Abstract

The invention discloses a purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury. The invention provides a purpose of a 3,4-dihydroxy phenyl substituted phenol compound including but not limited to protocatechuic acid, tanshinol, danshinolic acid B and danshinolic acid A for preparing the ALDH2 activating agent, and further provides a purpose of the 3,4-dihydroxy phenyl substituted phenol compound for preparing medicine for preventing and treating cardio-cerebral ischemia injury; a medicine composition for preventing and controlling myocardial infarction or cerebral apoplexy by 3,4-dihydroxy phenyl substituted phenol or pharmaceutical salts of the 3,4-dihydroxy phenyl substituted phenol. The 3,4-dihydroxy phenyl substituted phenol or pharmaceutical salts of the 3,4-dihydroxy phenyl substituted phenol can be used for preparing medicine for preventing and controlling diseases relevant to ALDH2.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new application of a compound, in particular to the application of 3,4-dihydroxyphenyl substituted phenol in the preparation of an ALDH2 activator and a drug for preventing and treating heart and brain ischemia injury. Background technique [0002] According to statistics, 3 million people die from ischemic cardiovascular and cerebrovascular diseases in my country every year, accounting for about 40% of all deaths. Ischemic cardiovascular and cerebrovascular diseases have become the diseases with the highest morbidity, disability and mortality in my country. . At present, many pathways related to cardio-cerebral ischemia injury have been discovered, and intervention of these pathways can reduce the damage of cardio-cerebral ischemia to cardiomyocytes and nerve cells (Reference: The Pathogenesis of Brain Injury Induced by Ischemia, Chinese Practical Medicine, Volume 3, Issue 25, September 2...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K31/216A61K31/192A61K31/11A61P9/10
CPCA61K31/11A61K31/192A61K31/216A61K31/343
Inventor 李萍杨华祁励丰荣蒋黎锋曾昊余莹华
Owner CHINA PHARM UNIV
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