Application of fructose 1,6-diphosphate in preparation of medicine for spontaneous abortion

A fructose diphosphate and spontaneous abortion technology, applied in the field of biomedicine, can solve the problems such as the unclear molecular mechanism of RSA
CN108387722BActive Publication Date: 2020-07-31THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
Publication Date
2020-07-31

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Abstract

The invention belongs to the technical field of medicines, and in particular discloses application of fructose 1,6-diphosphate (FDP) in preparation of a fetus protection medicine for spontaneous abortion. In vitro and in vivo animal experiments show that the concentration of the FDP in peripheral blood and decidual tissues of patients with recurrent spontaneous abortion is decreased compared withnormal pregnancy. Compared with control pregnant mice, the model plasma and uterus FDP levels of pregnant mice with spontaneous abortion are reduced, the uterus macrophage M2 phenotype molecule expression of the pregnant mice with spontaneous abortion is decreased, the proportions of helper cells T(Th)2 and regulatory T cells are reduced, and the phenomena of poor endometrium decidualization and decreased embryonic trophoblast infiltration degree occur in an accompanied way. The results indicate that the supplement of the FDP can significantly improve the uterine immune tolerance pattern, decidualization and embryonic trophoblast infiltration in the pregnant mice with spontaneous abortion, and obviously reduces embryonic loss in the pregnant mice. Therefore, the FDP is expected to be an early-warning and diagnostic indicator for the patients with spontaneous abortion, and can be used for preparing the fetus protection medicine for the spontaneous abortion.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to the application of fructose 1,6-diphosphate in the preparation of medicine for spontaneous abortion. In vitro experiments and in vivo animal experiments showed that compared with normal pregnancy, the concentration of fructose 1,6-diphosphate in peripheral blood and decidua tissue of patients with recurrent spontaneous abortion decreased. Compared with control pregnant mice, the plasma and uterine FDP levels of spontaneous abortion pregnant mice decreased, the expression of M2 phenotype molecules in uterine macrophages decreased, the proportion of helper cells T (Th) 2 and regulatory T cells decreased, and endometrial Poor decidualization and reduced infiltration of embryonic trophoblasts. The above results indicated that 1,6-diphosphate fructose supplementation could significantly improve the pattern of uterine immune tolerance, decidualization and embryonic trophoblast infil...

Claims

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