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Application of patchouli alcohol in preparation of drugs for prevention and treatment of renal injury

A technology for patchouli alcohol and kidney damage, applied in the field of patchouli alcohol in the field of preparing medicines for preventing and treating kidney damage, can solve problems such as no research and report on patchouli alcohol, achieve excellent application prospects and inhibit renal fibrosis. , improve the effect of pathological changes

Inactive Publication Date: 2018-08-17
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there are no relevant studies and reports on the prevention and treatment of (hypertensive) renal damage

Method used

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  • Application of patchouli alcohol in preparation of drugs for prevention and treatment of renal injury
  • Application of patchouli alcohol in preparation of drugs for prevention and treatment of renal injury
  • Application of patchouli alcohol in preparation of drugs for prevention and treatment of renal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 100

[0036] Therapeutic effect of embodiment 1 buccal alcohol on hypertensive renal damage

[0037] 1 Experimental materials

[0038] 1.1 Drugs and reagents

[0039]The patchouli medicinal material was collected from the patchouli planting base in Yangchun County, Guangdong Province in November 2012. It was identified as Pogostemoncablin (Blanco) by Dr. Long Fei from the Department of Traditional Chinese Medicine Identification, Chengdu University of Traditional Chinese Medicine. Benth.) whole herb.

[0040] Take 40Kg of the dried above-ground part of Patchouli medicinal material, use a large-scale improved steam distillation device to extract, dry and remove water through anhydrous sodium sulfate, and finally obtain 215g of Patchouli volatile oil. Use silica gel column chromatography (100-200 mesh, 5Kg, 20×150cm) to chromatographically separate the volatile oil, use petroleum ether-acetone (100:0-0:100) as the mobile phase for gradient elution, and the eluent passes through thin...

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Abstract

The invention relates to application of patchouli alcohol in the preparation of drugs for prevention and treatment of renal injury and also provides a drug to antagonize renal fibrosis to prevent or / and treat hypertensive renal injury. The drug is mainly made from patchouli alcohol or patchouli oil, or with other drugs, as well as pharmaceutically acceptable accessories or accessory ingredients. The drug provided herein can inhibit renal fibrosis and retard renal injury by: inhibiting RAS (renin-angiotensin system), down-regulating TGF-beta 1 and PAI-1 levels, inhibiting the proliferation andactivation of MFB, reducing matrix protein synthesis and ECM (extracellular deposition) and improving pathogenic change in kidney tissue. Therefore, the patchouli alcohol based on renal fibrosis inhibition has excellent application prospect in the prevention or / and treatment renal injury, particularly in the development of drugs for hypertensive renal injury.

Description

technical field [0001] The present invention relates to the application of bocchiol in the preparation of medicines for preventing and treating renal damage, in particular the application of the preparation of medicines for preventing and treating hypertensive renal damage. Background technique [0002] Renal damage refers to renal ischemia, hypoxia, renal parenchymal fibrosis and proteinuria due to spasm, sclerosis, degeneration and degeneration of renal arterioles, resulting in progressive decline of renal function, leading to the occurrence of uremia and other diseases. For hypertensive patients, prevention and treatment of kidney damage is particularly important. [0003] Hypertension is a common cause of kidney damage, which can eventually progress to end-stage renal disease (ESRD) that can only be treated by dialysis and kidney transplantation, seriously affecting the quality of life of patients. According to statistics, in my country, the number of patients with hype...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61P13/12A61P9/12A61K36/532
CPCA61K31/045A61K36/532A61P9/12A61P13/12
Inventor 彭成胡冠英谢晓芳熊亮
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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