Application of chloral hydrate in preparing metabolism regulator

A technology of chloral hydrate and regulators, which is applied in the direction of metabolic diseases, drug combinations, active ingredients of aldehydes, etc., and can solve problems such as rapid development

Pending Publication Date: 2018-08-17
NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The current state of research shows that although i

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  • Application of chloral hydrate in preparing metabolism regulator
  • Application of chloral hydrate in preparing metabolism regulator
  • Application of chloral hydrate in preparing metabolism regulator

Examples

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Embodiment 1

[0014] 1. This experiment explores the mechanism of blood biochemical changes caused by chloral hydrate disturbing metabolic disorders in rats by combining metabolomics analysis platform.

[0015] 2. Materials and methods

[0016] 2.1 Experimental animals

[0017] Twenty-seven 7-week-old male rats, weighing 200-300 g, were provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd. Experimental animal production license number: SCXK (Shanghai) 2013-0016, animals were kept in the barrier system of Nanjing Medical University Health Analysis and Testing Center (experimental animal use license number: SYXK (Su) 2015-0009), and used according to the experimental animal The 3R principle gives humane care.

[0018] 2.2 Instruments and reagents

[0019] Hitachi 7100 automatic blood biochemical instrument, UPLC Ultimate 3000system (Dionex) ultra-high performance liquid chromatography, Q-Exactive triple quadrupole tandem mass spectrometer, TraceFinder 3.1 software (Thermo Fisher ...

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Abstract

The invention belongs to the field of biochemistry and pharmacy, and discloses application of chloral hydrate in preparing a metabolism regulator. The metabonomics is adopted to research the influenceof the chloral hydrate on metabolism, and the application of the chloral hydrate in preparing the metabolism regulator is provided and has a better clinic application value.

Description

technical field [0001] The invention belongs to the fields of biochemistry and pharmacy, and relates to the application of chloral hydrate in the preparation of metabolic regulators. Background technique [0002] Chloral hydrate (chloral hydrate) is a chemical compound synthesized by the chlorination of ethanol. It is mainly used as an anesthetic, hypnotic and anticonvulsant in animal experiments and clinical medicine. Although this drug has not been certified by the US FDA and the European Union, and has certain clinical risks (1), it still has a certain market. Its scope of use mainly includes: experimental animals (rats, mice, etc.), adults, children, etc. (2,3)(4)(5,6). It can be seen that the use of chloral hydrate is quite extensive (7). Chloral hydrate is often used as a conventional anesthetic in animal experiments, which can cause changes in some biochemical indicators. [0003] Metabolomics is an emerging omics that is closer to phenotype than genomics, transcri...

Claims

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Application Information

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IPC IPC(8): A61K31/11A61P3/00A61P3/08
CPCA61K31/11A61P3/00A61P3/08
Inventor 王玉邦胡艳辉环飞张静姝陈敏健张蕾王笑笑
Owner NANJING MEDICAL UNIV
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