Chlortetracycline hydrochloride bacterial endotoxin inspection equipment and method

A technology of bacterial endotoxin and chlortetracycline hydrochloride, which is applied in the field of biological experiments, can solve the problem of no bacterial endotoxin of chlortetracycline hydrochloride, etc., and achieve the effects of reasonable equipment structure design, simple inspection steps, and improved efficiency

Active Publication Date: 2018-08-17
辰欣佛都药业(汶上)有限公司
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Problems solved by technology

In the implementation standard of "Chinese Pharmacopoeia", there is a legal standard for aureomycin hydrochloride that has been verified, but there is still no inspection item for bacterial endotoxin of aureomycin hydrochloride. Chlortetracycline hydrochloride usually will be made into aseptic eye ointment, so in order to ensure the production quality

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  • Chlortetracycline hydrochloride bacterial endotoxin inspection equipment and method

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Embodiment Construction

[0022] In order to clearly illustrate the technical features of the solution, the present invention will be described in detail below through specific embodiments and in conjunction with the accompanying drawings.

[0023] like figure 1 As shown in the chlortetracycline hydrochloride bacterial endotoxin testing equipment, it includes a standard solution preparation device 1, a test solution preparation device 2, and a Limulus reagent preparation device 3; the standard solution preparation device 1 includes a first fixing frame 37. , a first mixing chamber 4 is fixedly connected to one side of the first fixing frame 37, a first water filtration membrane 5 is arranged in the top opening pipe of the first mixing chamber 4, and a national standard product of bacterial endotoxin is taken when preparing the standard solution Or a working standard product, flick the bottle wall to make the powder fall into the bottom of the bottle, then use a grinding wheel to gently scratch the uppe...

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Abstract

The invention relates to the field of biological experiments, in particular to chlortetracycline hydrochloride bacterial endotoxin inspection equipment and method. The chlortetracycline hydrochloridebacterial endotoxin inspection equipment comprises a standard liquid preparation device, a test solution preparation device and a tachypleus amebocyte lysate preparation device; the standard liquid preparation device comprises a first fixed frame; one side of the first fixed frame is fixedly connected with a first mixing chamber; an opening tube on the top of the first mixing chamber is internallyprovided with a first water filter membrane; the opening tube on the top of the first mixing chamber is provided with an end cover; the side wall of an opening tube at the upper part of the first water filter membrane is provided with a dissolved water supply tube which is connected with an external supply end in a communicating manner; and the dissolved water supply tube is provided with a dissolution flowrate valve. The chlortetracycline hydrochloride bacterial endotoxin inspection equipment is reasonable in structure design and simple in inspection step, can rapidly and accurately performaccurate judgement on the content of chlortetracycline hydrochloride bacterial endotoxin, more effectively meets the demands of people and solves the problem in the prior art.

Description

technical field [0001] The invention relates to the field of biological experiments, in particular to an equipment and a method for testing the bacterial endotoxin of chlortetracycline hydrochloride. Background technique [0002] As a medical treatment drug, chlortetracycline hydrochloride is mainly used to treat conjunctivitis, trachoma and other diseases. Therefore, a large number of chlortetracycline hydrochloride are currently used to make sterile eye ointment. There are legal standards for chlortetracycline hydrochloride that have been verified in the implementation standards of the "Chinese Pharmacopoeia", but there is still no inspection item for bacterial endotoxin of chlortetracycline hydrochloride. When chlortetracycline hydrochloride is usually made as a sterile preparation eye ointment, in order to ensure the production quality of the drug, it is necessary to test the parameter of chlortetracycline hydrochloride bacterial endotoxin. Some bacterial endotoxin test...

Claims

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Application Information

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IPC IPC(8): G01N33/579G01N1/28
CPCG01N1/28G01N33/579Y02A50/30
Inventor 张华刘东升毕晓文朱珠黄兴士
Owner 辰欣佛都药业(汶上)有限公司
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